ENSMUSG00000027323


Mus musculus

Features
Gene ID: ENSMUSG00000027323
  
Biological name :Rad51
  
Synonyms : DNA repair 1 / Q08297 / Rad51
  
Possible biological names infered from orthology : AC012476.1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119112793
Gene end: 119147445
  
Corresponding Affymetrix probe sets: 10474902 (MoGene1.0st)   1418281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117939
Ensembl peptide - ENSMUSP00000119444
Ensembl peptide - ENSMUSP00000119101
Ensembl peptide - ENSMUSP00000028795
NCBI entrez gene - 19361     See in Manteia.
MGI - MGI:97890
RefSeq - NM_011234
RefSeq Peptide - NP_035364
swissprot - A3KGI2
swissprot - F7AT35
swissprot - D6RCK1
swissprot - Q08297
Ensembl - ENSMUSG00000027323
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad51ENSDARG00000041411Danio rerio
 RAD51ENSGALG00000030313Gallus gallus
 AC012476.1ENSG00000285396Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010995  DNA repair Rad51/transcription factor NusA, alpha-helical
 IPR011941  DNA recombination/repair protein Rad51
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020587  DNA recombination and repair protein RecA, monomer-monomer interface
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000722 telomere maintenance via recombination IGI
 biological_processGO:0000724 double-strand break repair via homologous recombination ISO
 biological_processGO:0000730 DNA recombinase assembly ISO
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006268 DNA unwinding involved in DNA replication ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007127 meiosis I IEA
 biological_processGO:0007131 reciprocal meiotic recombination TAS
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination ISS
 biological_processGO:0010833 telomere maintenance via telomere lengthening IGI
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031297 replication fork processing ISO
 biological_processGO:0032200 telomere organization IMP
 biological_processGO:0036297 interstrand cross-link repair ISS
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0051106 positive regulation of DNA ligation ISO
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0051321 meiotic cell cycle IDA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IMP
 biological_processGO:0071312 cellular response to alkaloid IMP
 biological_processGO:0071479 cellular response to ionizing radiation ISS
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0072711 cellular response to hydroxyurea IMP
 biological_processGO:0072719 cellular response to cisplatin IEA
 biological_processGO:0072757 cellular response to camptothecin ISO
 biological_processGO:1904631 response to glucoside IEA
 biological_processGO:1990414 replication-born double-strand break repair via sister chromatid exchange IMP
 biological_processGO:1990426 mitotic recombination-dependent replication fork processing IEA
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex TAS
 cellular_componentGO:0000800 lateral element ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0035861 site of double-strand break ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISO
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity ISS
 molecular_functionGO:0070182 DNA polymerase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rad51tm1Hst/Rad51tm1Hst,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Rad51tm1Hst/Rad51tm1Hst,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012142 absent amniotic cavity "absence of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
Show

Allelic Composition: Ighg1tm1Ksho/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr