ENSGALG00000042418


Gallus gallus

Features
Gene ID: ENSGALG00000042418
  
Biological name :CHEK1
  
Synonyms : CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1
  
Possible biological names infered from orthology : checkpoint kinase 1 / O14757 / O35280
  
Species: Gallus gallus
  
Chr. number: 24
Strand: -1
Band:
Gene start: 376425
Gene end: 380172
  
Corresponding Affymetrix probe sets: Gga.4288.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047725
NCBI entrez gene - 374260     See in Manteia.
RefSeq - XM_015297939
RefSeq - NM_204345
RefSeq - XM_015297941
RefSeq Peptide - NP_989676
swissprot - Q8AYC9
Ensembl - ENSGALG00000042418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chek1ENSDARG00000104765Danio rerio
 CHEK1ENSG00000149554Homo sapiens
 Chek1ENSMUSG00000032113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SBK1 / SH3 domain binding kinase 1 / Q52WX2* / Q8QZX0* / Serine/threonine-protein kinase SBK1 *ENSGALG0000001417918
SBK2 / SH3 domain binding kinase family member 2 / P0C263* / P0C5K1* / Serine/threonine-protein kinase SBK2 *ENSGALG0000001303516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint ISS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0001833 inner cell mass cell proliferation IEA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0006975 DNA damage induced protein phosphorylation ISS
 biological_processGO:0006997 nucleus organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination ISS
 biological_processGO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0035407 histone H3-T11 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISS
 biological_processGO:0046602 regulation of mitotic centrosome separation ISS
 biological_processGO:0048096 chromatin-mediated maintenance of transcription IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISS
 biological_processGO:1902742 apoptotic process involved in development IEA
 biological_processGO:2000615 regulation of histone H3-K9 acetylation IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000794 condensed nuclear chromosome ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035402 histone kinase activity (H3-T11 specific) IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Activation of ATR in response to replication stress
Chk1-controlled and DNA-damage induced centrosome duplication
ATM mediated phosphorylation of repair proteins
Homologous recombination repair of replication-dependent double-strand breaks
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000017073 BRCA2 / BRCA2, DNA repair associated / P51587* / P97929* / Breast cancer type 2 susceptibility protein homolog *  / reaction
 ENSGALG00000007649 TIPIN / TIMELESS-interacting protein / Q91WA1* / Q9BVW5*  / reaction
 ENSGALG00000016454 E2F6 / E2F transcription factor 6 / O54917* / O75461* / Transcription factor E2F6 *  / reaction
 ENSGALG00000030313 RAD51 / P37383 / DNA repair protein RAD51 homolog 1 / Q08297* / Q06609* / AC012476.1* / DNA repair 1 * / RAD51 recombinase*  / reaction
 ENSGALG00000038469 CDC25A / cell division cycle 25A / P30304* / P48964* / M-phase inducer phosphatase 1 *  / reaction






 

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