ENSGALG00000016454


Gallus gallus

Features
Gene ID: ENSGALG00000016454
  
Biological name :E2F6
  
Synonyms : E2F6 / E2F transcription factor 6
  
Possible biological names infered from orthology : O54917 / O75461 / Transcription factor E2F6
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 97732869
Gene end: 97743301
  
Corresponding Affymetrix probe sets: Gga.10827.1.S1_at (Chicken Array)   GgaAffx.11638.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046246
Ensembl peptide - ENSGALP00000030960
NCBI entrez gene - 421943     See in Manteia.
RefSeq - XM_015276043
RefSeq - NM_001244738
RefSeq Peptide - NP_001231667
swissprot - Q5ZM49
swissprot - E1C979
Ensembl - ENSGALG00000016454
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-195d17.2ENSDARG00000008119Danio rerio
 E2F6ENSG00000169016Homo sapiens
 E2f6ENSMUSG00000057469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F3 / E2F transcription factor 3 / O00716* / O35261* / Transcription factor E2F3 *ENSGALG0000001268044
E2F1 / transcription factor E2F1 / Q01094* / Q61501* / E2F transcription factor 1*ENSGALG0000000304540
E2F5 / transcription factor E2F5 / Q15329* / Q61502* / E2F transcription factor 5*ENSGALG0000003891529
E2F4 / E2F transcription factor 4 / Q16254* / Q8R0K9* / Transcription factor E2F4 *ENSGALG0000000172228


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015633  E2F Family
 IPR015635  Transcription factor E2F6
 IPR032198  E2F transcription factor, CC-MB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014060 EED / Q5ZKH3 / Polycomb protein EED / O75530* / Q921E6* / embryonic ectoderm development*  / complex / reaction
 ENSGALG00000008230 PCGF6 / polycomb group ring finger 6 / Q99NA9* / Q9BYE7* / Polycomb group RING finger protein 6 *  / reaction / complex
 ENSGALG00000016823 TFDP1* / TFDP3* / Q5H9I0* / Q08639* / Q14186* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex / reaction
 ENSGALG00000043399 EZH2 / enhancer of zeste 2 polycomb repressive complex 2 subunit / Q15910* / Q61188* / Histone-lysine N-methyltransferase EZH2 *  / reaction / complex
 ENSGALG00000007169 EPC1 / enhancer of polycomb homolog 1 / Q8C9X6* / Q9H2F5*  / reaction / complex
 ENSGALG00000011038 CBX3 / Q13185* / chromobox 3* / chromobox protein homolog 3 *  / complex / reaction
 ENSGALG00000009540 YAF2 / YY1 associated factor 2 / Q8IY57* / Q99LW6*  / complex / reaction
 ENSGALG00000011976 L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit / P59178* / Q969R5* / Lethal(3)malignant brain tumor-like protein 2 *  / complex / reaction
 ENSGALG00000037219 RNF2 / ring finger protein 2 / Q99496* / Q9CQJ4* / E3 ubiquitin-protein ligase RING2 *  / complex / reaction
 ENSGALG00000025759 TFDP2 / transcription factor Dp-2 / Q14188*  / reaction / complex
 ENSGALG00000042418 CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1 / O14757* / O35280* / checkpoint kinase 1*  / reaction






 

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