ENSGALG00000043399


Gallus gallus

Features
Gene ID: ENSGALG00000043399
  
Biological name :EZH2
  
Synonyms : enhancer of zeste 2 polycomb repressive complex 2 subunit / EZH2
  
Possible biological names infered from orthology : Histone-lysine N-methyltransferase EZH2 / Q15910 / Q61188
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 54453671
Gene end: 54500690
  
Corresponding Affymetrix probe sets: Gga.20057.1.S1_s_at (Chicken Array)   Gga.4473.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054289
NCBI entrez gene - 420784     See in Manteia.
RefSeq - XM_004935062
RefSeq - XM_015275908
RefSeq - XM_015275909
RefSeq - XM_015275910
RefSeq - XM_015275912
RefSeq - XM_418879
RefSeq - XM_004935061
swissprot - A0A1D5PN50
Ensembl - ENSGALG00000043399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ezh2ENSDARG00000010571Danio rerio
 EZH2ENSG00000106462Homo sapiens
 Ezh2ENSMUSG00000029687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EZH1 / enhancer of zeste 1 polycomb repressive complex 2 subunit / P70351* / Q92800* / Histone-lysine N-methyltransferase EZH1 *ENSGALG0000000306865
EHMT1 / histone-lysine N-methyltransferase EHMT1 / Q5DW34* / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSGALG0000003367816
NSD1 / nuclear receptor binding SET domain protein 1 / Q96L73*ENSGALG0000000297115
NSD3 / nuclear receptor binding SET domain protein 3 / Q6P2L6* / Q9BZ95* / Histone-lysine N-methyltransferase NSD3 *ENSGALG0000000329914
NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *ENSGALG0000001570514
SETD2 / SET domain containing 2 / E9Q5F9* / Q9BYW2* / Histone-lysine N-methyltransferase SETD2 *ENSGALG0000004205114
ASH1L / ASH1 like histone lysine methyltransferase / Q99MY8* / Q9NR48* / Histone-lysine N-methyltransferase ASH1L *ENSGALG0000001463814
SETDB1 / SET domain bifurcated 1 / Q15047*ENSGALG0000002405113
SETBP1 / SET binding protein 1 / Q9Y6X0* / Q9Z180* / SET-binding protein *ENSGALG0000003677511
SETDB2 / SET domain bifurcated 2 / Q8C267* / Q96T68*ENSGALG0000001700610
Q5F3W5 / SUV39H2 / Histone-lysine N-methyltransferase SUV39H2 / Q9H5I1* / suppressor of variegation 3-9 2* / suppressor of variegation 3-9 homolog 2*ENSGALG0000001392010


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR001214  SET domain
 IPR021654  Histone-lysine N-methyltransferase EZH1/EZH2
 IPR026489  CXC domain
 IPR033467  Tesmin/TSO1-like CXC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0014013 regulation of gliogenesis IEA
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0021695 cerebellar cortex development IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0035984 cellular response to trichostatin A IEA
 biological_processGO:0036333 hepatocyte homeostasis IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045605 negative regulation of epidermal cell differentiation IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0051154 negative regulation of striated muscle cell differentiation IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070314 G1 to G0 transition IEA
 biological_processGO:0070734 histone H3-K27 methylation IEA
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0098532 histone H3-K27 trimethylation IEA
 biological_processGO:1904772 response to tetrachloromethane IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 cellular_componentGO:0045120 pronucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) IEA
 molecular_functionGO:0070878 primary miRNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007169 EPC1 / enhancer of polycomb homolog 1 / Q8C9X6* / Q9H2F5*  / reaction / complex
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / complex / reaction
 ENSGALG00000016454 E2F6 / E2F transcription factor 6 / O54917* / O75461* / Transcription factor E2F6 *  / complex / reaction
 ENSGALG00000016823 TFDP1* / TFDP3* / Q5H9I0* / Q08639* / Q14186* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / complex / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000014060 EED / Q5ZKH3 / Polycomb protein EED / O75530* / Q921E6* / embryonic ectoderm development*  / complex
 ENSGALG00000041461 DNMT3B / DNA methyltransferase 3 beta / Dnmt3c* / Q9UBC3* / O88509* / DNA (cytosine-5)-methyltransferase 3B *  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr