ENSGALG00000015705


Gallus gallus

Features
Gene ID: ENSGALG00000015705
  
Biological name :NSD2
  
Synonyms : NSD2 / nuclear receptor binding SET domain protein 2
  
Possible biological names infered from orthology : Histone-lysine N-methyltransferase NSD2 / O96028 / Q8BVE8
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 83802147
Gene end: 83861078
  
Corresponding Affymetrix probe sets: Gga.10435.1.S1_s_at (Chicken Array)   Gga.1221.1.S1_at (Chicken Array)   GgaAffx.20413.1.S1_at (Chicken Array)   GgaAffx.24753.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025281
NCBI entrez gene - 422897     See in Manteia.
RefSeq - XM_015285996
RefSeq - XM_015285997
RefSeq - XM_015285998
RefSeq - XM_015285999
RefSeq - XM_015286000
RefSeq - XM_015286001
RefSeq - XM_015286003
RefSeq - XM_015286004
RefSeq - XM_015286005
RefSeq - XM_015286006
RefSeq - XM_015286007
RefSeq - XM_015285995
swissprot - E1C765
Ensembl - ENSGALG00000015705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsd2ENSDARG00000026225Danio rerio
 NSD2ENSG00000109685Homo sapiens
 Nsd2ENSMUSG00000057406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NSD3 / nuclear receptor binding SET domain protein 3 / Q6P2L6* / Q9BZ95* / Histone-lysine N-methyltransferase NSD3 *ENSGALG0000000329945
NSD1 / nuclear receptor binding SET domain protein 1 / Q96L73*ENSGALG0000000297143
ASH1L / ASH1 like histone lysine methyltransferase / Q99MY8* / Q9NR48* / Histone-lysine N-methyltransferase ASH1L *ENSGALG0000001463816
SETD2 / SET domain containing 2 / E9Q5F9* / Q9BYW2* / Histone-lysine N-methyltransferase SETD2 *ENSGALG0000004205116
EHMT1 / histone-lysine N-methyltransferase EHMT1 / Q5DW34* / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSGALG0000003367813
SETDB1 / SET domain bifurcated 1 / Q15047*ENSGALG0000002405110
SETBP1 / SET binding protein 1 / Q9Y6X0* / Q9Z180* / SET-binding protein *ENSGALG000000367759
EZH2 / enhancer of zeste 2 polycomb repressive complex 2 subunit / Q15910* / Q61188* / Histone-lysine N-methyltransferase EZH2 *ENSGALG000000433998
EZH1 / enhancer of zeste 1 polycomb repressive complex 2 subunit / P70351* / Q92800* / Histone-lysine N-methyltransferase EZH1 *ENSGALG000000030688
SETDB2 / SET domain bifurcated 2 / Q8C267* / Q96T68*ENSGALG000000170066
Q5F3W5 / SUV39H2 / Histone-lysine N-methyltransferase SUV39H2 / Q9H5I1* / suppressor of variegation 3-9 2* / suppressor of variegation 3-9 homolog 2*ENSGALG000000139206


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001214  SET domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR006560  AWS domain
 IPR009071  High mobility group box domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0003149 membranous septum morphogenesis IEA
 biological_processGO:0003289 atrial septum primum morphogenesis IEA
 biological_processGO:0003290 atrial septum secundum morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010452 histone H3-K36 methylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034770 histone H4-K20 methylation IEA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0070201 regulation of establishment of protein localization IEA
 biological_processGO:2001032 regulation of double-strand break repair via nonhomologous end joining IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / reaction / complex
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / complex / reaction
 ENSGALG00000012484 RIF1 / E1C2U2 / Telomere-associated protein RIF1 / Q6PR54* / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / complex / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / reaction / complex
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction






 

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