ENSGALG00000016739


Gallus gallus

Features
Gene ID: ENSGALG00000016739
  
Biological name :HERC2
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase 2 / HERC2
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase HERC2 / O95714 / Q4U2R1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 130548138
Gene end: 130652716
  
Corresponding Affymetrix probe sets: Gga.14509.1.S1_s_at (Chicken Array)   Gga.16691.1.S1_at (Chicken Array)   Gga.17764.1.S1_s_at (Chicken Array)   Gga.8950.1.S1_at (Chicken Array)   GgaAffx.10708.1.S1_at (Chicken Array)   GgaAffx.25050.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026967
NCBI entrez gene - 418682     See in Manteia.
RefSeq - XM_015277713
RefSeq - NM_001252376
RefSeq - XM_015277711
RefSeq - XM_015277712
RefSeq Peptide - NP_001239305
swissprot - E1BW48
Ensembl - ENSGALG00000016739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herc2ENSDARG00000073841Danio rerio
 HERC2ENSG00000128731Homo sapiens
 Herc2ENSMUSG00000030451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HERC1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSGALG0000000338124
HERC4 / HECT and RLD domain containing E3 ubiquitin protein ligase 4 / Q5GLZ8* / Q6PAV2* / Probable E3 ubiquitin-protein ligase HERC4 *ENSGALG000000038614
HERC5* / HERC6* / Q9UII4* / F2Z461* / Q8IVU3* / AC098582.1* / E3 ISG15--protein ligase Herc6 * / HECT and RLD domain containing E3 ubiquitin protein ligase 5* / HECT and RLD domain containi...ENSGALG000000420014
HERC3 / probable E3 ubiquitin-protein ligase HERC3 / Q15034* / HECT and RLD domain containing E3 ubiquitin protein ligase 3*ENSGALG000000103634
HECTD3* / Q3U487* / Q5T447* / E3 ubiquitin-protein ligase HECTD3 * / HECT domain E3 ubiquitin protein ligase 3*ENSGALG000000102173
HECTD3* / Q3U487* / Q5T447* / E3 ubiquitin-protein ligase HECTD3 * / HECT domain E3 ubiquitin protein ligase 3*ENSGALG000000102033
UBE3A / ubiquitin protein ligase E3A / O08759* / Q05086*ENSGALG000000349442
HECTD2 / HECT domain E3 ubiquitin protein ligase 2 / Q5U5R9* / Q8CDU6* / Probable E3 ubiquitin-protein ligase HECTD2 *ENSGALG000000380432
ENSGALG000000232371


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000433  Zinc finger, ZZ-type
 IPR000569  HECT domain
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR004939  APC10/DOC domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR010606  Mib-herc2
 IPR014722  Ribosomal protein L2, domain 2
 IPR021097  CPH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / reaction / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction / complex
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / reaction / complex
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000012484 RIF1 / E1C2U2 / Telomere-associated protein RIF1 / Q6PR54* / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction






 

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