ENSGALG00000006428


Gallus gallus

Features
Gene ID: ENSGALG00000006428
  
Biological name :UBE2I
  
Synonyms : P63283 / SUMO-conjugating enzyme UBC9 / UBE2I
  
Possible biological names infered from orthology : P63279 / P63280 / ubiquitin conjugating enzyme E2 I
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 7446388
Gene end: 7459728
  
Corresponding Affymetrix probe sets: Gga.4940.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060563
Ensembl peptide - ENSGALP00000010363
Ensembl peptide - ENSGALP00000045009
Ensembl peptide - ENSGALP00000048004
NCBI entrez gene - 374123     See in Manteia.
RefSeq - XM_015294115
RefSeq - NM_204265
RefSeq - XM_015294112
RefSeq - XM_015294113
RefSeq - XM_015294114
RefSeq - XM_015294110
RefSeq - XM_015294111
RefSeq Peptide - NP_989596
swissprot - P63283
swissprot - A0A1L1RP41
Ensembl - ENSGALG00000006428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9DDJ0ENSDARG00000052649Danio rerio
 Q9W6H5ENSDARG00000007438Danio rerio
 UBE2IENSG00000103275Homo sapiens
 Ube2iENSMUSG00000015120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site
 IPR027230  SUMO-conjugating enzyme Ubc9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1903755 positive regulation of SUMO transferase activity IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:1990234 transferase complex IEA
 cellular_componentGO:1990356 sumoylated E2 ligase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IBA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0043398 HLH domain binding IEA
 molecular_functionGO:0044388 small protein activating enzyme binding IEA
 molecular_functionGO:0061656 SUMO conjugating enzyme activity IEA
 molecular_functionGO:0071535 RING-like zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002803 MTA1 / metastasis-associated protein MTA1 / Q13330* / Q8K4B0* / metastasis associated 1* / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / reaction
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / reaction
 ENSGALG00000007690 TFAP2C / transcription factor AP-2 gamma / Q61312* / Q92754*  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000013365 SAFB* / SAFB2* / Q80YR5* / D3YXK2* / Q14151* / Q15424* / scaffold attachment factor B* / scaffold attachment factor B2* / Scaffold attachment factor B1 *  / reaction
 ENSGALG00000031457 TDG / thymine DNA glycosylase / P56581* / Q13569* / Mus musculus thymine DNA glycosylase (Tdg), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / reaction
 ENSGALG00000037360 DDX17 / DEAD-box helicase 17 / Q501J6* / Q92841* / Probable ATP-dependent RNA helicase DDX17 *  / reaction
 ENSGALG00000001644 SIN3A / SIN3 transcription regulator family member A / Q60520* / Q96ST3* / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA.*  / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / complex / reaction
 ENSGALG00000016617 NCOA1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction
 ENSGALG00000042491 P62801 / Histone H4   / reaction
 ENSGALG00000020523 TOPORS / TOP1 binding arginine/serine rich protein / Q80Z37* / Q9NS56* / E3 ubiquitin-protein ligase Topors *  / reaction
 ENSGALG00000004288 HDAC4 / P83038 / Histone deacetylase 4 / P56524* / Q6NZM9*  / reaction
 ENSGALG00000045534 PML* / P29590* / Q60953* / Protein PML * / promyelocytic leukemia*  / reaction
 ENSGALG00000036214 PARK7 / protein/nucleic acid deglycase DJ-1 / Q99497* / Q99LX0* / Parkinsonism associated deglycase*  / reaction
 ENSGALG00000011254 SATB1 / SATB homeobox 1 / Q01826* / Q60611* / Mus musculus special AT-rich sequence binding protein 1 (Satb1), transcript variant 5, mRNA.*  / reaction
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / reaction
 ENSGALG00000029282 FOXL2 / forkhead box L2 / O88470* / P58012* / Forkhead box protein L2 *  / reaction
 ENSGALG00000001948 SAFB* / SAFB2* / Q80YR5* / D3YXK2* / Q14151* / Q15424* / scaffold attachment factor B* / scaffold attachment factor B2* / Scaffold attachment factor B1 *  / reaction
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / reaction
 ENSGALG00000031796 SP3 / Q90WR8 / Transcription factor Sp3 / Q02447* / O70494* / Sp3 transcription factor*  / reaction
 ENSGALG00000001080 NR5A1 / steroidogenic factor 1 / P33242* / Q13285* / nuclear receptor subfamily 5 group A member 1*  / reaction
 ENSGALG00000015681 NRIP1 / nuclear receptor interacting protein 1 / P48552* / Q8CBD1* / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000011294 THRB / P68306 / Thyroid hormone receptor beta / P10828* / P37242*  / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / reaction
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / reaction
 ENSGALG00000008135 SATB2 / SATB homeobox 2 / Q8VI24* / Q9UPW6* / special AT-rich sequence binding protein 2*  / reaction
 ENSGALG00000005006 UBA2 / SUMO-activating enzyme subunit 2 / Q9UBT2* / Q9Z1F9* / ubiquitin like modifier activating enzyme 2*  / reaction
 ENSGALG00000015620 XRCC4 / X-ray repair cross complementing 4 / Q13426* / X-ray repair complementing defective repair in Chinese hamster cells 4*  / reaction
 ENSGALG00000014859 P52739* / Q8K3J5* / Zfp131* / ZNF131* / zinc finger protein 131*  / reaction
 ENSGALG00000011976 L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit / P59178* / Q969R5* / Lethal(3)malignant brain tumor-like protein 2 *  / reaction
 ENSGALG00000011300 TOP2B / DNA topoisomerase 2-beta / Q02880* / Q64511* / DNA topoisomerase II beta*  / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSGALG00000011966 RANGAP1 / ran GTPase-activating protein 1 / P46060* / P46061*  / complex
 ENSGALG00000010035 NR3C2 / mineralocorticoid receptor / P08235* / nuclear receptor subfamily 3 group C member 2*  / reaction
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSGALG00000011594 NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *  / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction
 ENSGALG00000003922 TOP2A / DNA topoisomerase 2-alpha / P11388* / Q01320* / DNA topoisomerase II alpha*  / reaction
 ENSGALG00000039171 RAD52 / DNA repair protein RAD52 homolog isoform 2 / P43351* / P43352* / RAD52 homolog, DNA repair protein*  / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / reaction
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / reaction
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / reaction
 ENSGALG00000039583 MITF / microphthalmia-associated transcription factor / O75030* / Q08874* / melanogenesis associated transcription factor*  / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / reaction
 ENSGALG00000038059 NR1H3 / nuclear receptor subfamily 1 group H member 3 / Q13133* / Q9Z0Y9* / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000032992 NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*  / reaction
 ENSGALG00000039942 CTBP1 / C-terminal-binding protein 1 / O88712* / Q13363*  / reaction
 ENSGALG00000041470 PPARA / peroxisome proliferator-activated receptor alpha / P23204* / Q07869*  / reaction
 ENSGALG00000041461 DNMT3B / DNA methyltransferase 3 beta / Dnmt3c* / Q9UBC3* / O88509* / DNA (cytosine-5)-methyltransferase 3B *  / reaction
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / reaction






 

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