ENSGALG00000011594


Gallus gallus

Features
Gene ID: ENSGALG00000011594
  
Biological name :NR1H4
  
Synonyms : NR1H4 / nuclear receptor subfamily 1 group H member 4
  
Possible biological names infered from orthology : Bile acid receptor / Q60641 / Q96RI1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 47358279
Gene end: 47391069
  
Corresponding Affymetrix probe sets: Gga.127.1.S1_at (Chicken Array)   Gga.14710.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018906
NCBI entrez gene - 373902     See in Manteia.
RefSeq - NM_204113
RefSeq Peptide - NP_989444
swissprot - Q8JHU2
Ensembl - ENSGALG00000011594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1h4ENSDARG00000057741Danio rerio
 NR1H4ENSG00000012504Homo sapiens
 Nr1h4ENSMUSG00000047638Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr1h5*ENSGALG0000000217051
NR1H3 / nuclear receptor subfamily 1 group H member 3 / Q13133* / Q9Z0Y9* / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA.*ENSGALG0000003805931
THRB / P68306 / Thyroid hormone receptor beta / P10828* / P37242*ENSGALG0000001129426
THRA / Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA. / P10827* / P63058* / thyroid hormone receptor, alpha*ENSGALG0000004001724
RARB / P22448 / Retinoic acid receptor beta / P10826* / P22605*ENSGALG0000001129823
RARA / retinoic acid receptor alpha / P10276* / P11416*ENSGALG0000003793523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007043 cell-cell junction assembly IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008206 bile acid metabolic process IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010988 regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032692 negative regulation of interleukin-1 production IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IEA
 biological_processGO:0034255 regulation of urea metabolic process IEA
 biological_processGO:0034971 histone H3-R17 methylation IEA
 biological_processGO:0035356 cellular triglyceride homeostasis IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0038183 bile acid signaling pathway IEA
 biological_processGO:0038185 intracellular bile acid receptor signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0055089 fatty acid homeostasis IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 biological_processGO:0070858 negative regulation of bile acid biosynthetic process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071417 cellular response to organonitrogen compound IEA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0072615 interleukin-17 secretion IEA
 biological_processGO:1902714 negative regulation of interferon-gamma secretion IEA
 biological_processGO:1904179 positive regulation of adipose tissue development IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905695 positive regulation of phosphatidic acid biosynthetic process IEA
 biological_processGO:2000213 positive regulation of glutamate metabolic process IEA
 biological_processGO:2001250 positive regulation of ammonia assimilation cycle IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0032052 bile acid binding IEA
 molecular_functionGO:0038181 bile acid receptor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:1902122 chenodeoxycholic acid binding IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000016617 NCOA1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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