ENSGALG00000040017


Gallus gallus

Features
Gene ID: ENSGALG00000040017
  
Biological name :THRA
  
Synonyms : Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA. / THRA
  
Possible biological names infered from orthology : P10827 / P63058 / thyroid hormone receptor, alpha
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 4626754
Gene end: 4775528
  
Corresponding Affymetrix probe sets: Gga.725.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050455
Ensembl peptide - ENSGALP00000057478
Ensembl peptide - ENSGALP00000052375
NCBI entrez gene - 396251     See in Manteia.
RefSeq - NM_205313
RefSeq - XM_015299560
RefSeq Peptide - NP_990644
swissprot - A0A1D5PWY8
swissprot - A0A1D5PCG7
Ensembl - ENSGALG00000040017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thraaENSDARG00000000151Danio rerio
 thrabENSDARG00000052654Danio rerio
 THRAENSG00000126351Homo sapiens
 ThraENSMUSG00000058756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THRB / P68306 / Thyroid hormone receptor beta / P10828* / P37242*ENSGALG0000001129481
RARA / retinoic acid receptor alpha / P10276* / P11416*ENSGALG0000003793533
RARB / P22448 / Retinoic acid receptor beta / P10826* / P22605*ENSGALG0000001129833
NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSGALG0000001159428
NR1H3 / nuclear receptor subfamily 1 group H member 3 / Q13133* / Q9Z0Y9* / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA.*ENSGALG0000003805927
Nr1h5*ENSGALG0000000217027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0008050 female courtship behavior IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IEA
 biological_processGO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0033032 regulation of myeloid cell apoptotic process IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045925 positive regulation of female receptivity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050994 regulation of lipid catabolic process IEA
 biological_processGO:0060509 type I pneumocyte differentiation IEA
 biological_processGO:2000143 negative regulation of DNA-templated transcription, initiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0002153 steroid receptor RNA activator RNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070324 thyroid hormone binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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