Manteia - Molecule gene

ENSMUSG00000058756

Mus musculus

Features

Gene ID:	ENSMUSG00000058756

Biological name :	Thra

Synonyms :	P63058 / Thra / Thyroid hormone receptor alpha

Possible biological names infered from orthology :	P10827

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	98740638
Gene end:	98769006

Corresponding Affymetrix probe sets:	10381006 (MoGene1.0st) 1426997_at (Mouse Genome 430 2.0 Array) 1443952_at (Mouse Genome 430 2.0 Array) 1454675_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000099428 Ensembl peptide - ENSMUSP00000123056 Ensembl peptide - ENSMUSP00000115323 Ensembl peptide - ENSMUSP00000068281 NCBI entrez gene - 21833 See in Manteia. MGI - MGI:98742 RefSeq - NM_001313983 RefSeq - NM_178060 RefSeq Peptide - NP_001300912 RefSeq Peptide - NP_835161 swissprot - P63058 swissprot - A0A0R4J1R8 swissprot - A3KFN7 Ensembl - ENSMUSG00000058756

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
thraa	ENSDARG00000000151	Danio rerio
thrab	ENSDARG00000052654	Danio rerio
THRA	ENSGALG00000040017	Gallus gallus
THRA	ENSG00000126351	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Thrb / P37242 / Thyroid hormone receptor beta / P10828*	ENSMUSG00000021779	59
Rara / P11416 / retinoic acid receptor, alpha / P10276*	ENSMUSG00000037992	27
Rarb / P22605 / retinoic acid receptor, beta / P10826*	ENSMUSG00000017491	27
Rarg / P18911 / Retinoic acid receptor gamma / P13631*	ENSMUSG00000001288	27
Nr1i2 / O54915 / Nuclear receptor subfamily 1 group I member 2 / O75469*	ENSMUSG00000022809	23
Nr1h2 / Q60644 / Oxysterols receptor LXR-beta / P55055* / nuclear receptor subfamily 1 group H member 2*	ENSMUSG00000060601	23
Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*	ENSMUSG00000047638	23
Nr1h3 / Q9Z0Y9 / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133* / nuclear receptor subfamily 1 group H member 3*	ENSMUSG00000002108	23
Nr1h5	ENSMUSG00000048938	22
Vdr / P48281 / vitamin D (1,25-dihydroxyvitamin D3) receptor / P11473* / vitamin D receptor*	ENSMUSG00000022479	21
Nr1i3 / O35627 / Nuclear receptor subfamily 1 group I member 3 / Q14994*	ENSMUSG00000005677	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000536	Nuclear hormone receptor, ligand-binding domain
IPR001628	Zinc finger, nuclear hormone receptor-type
IPR001723	Nuclear hormone receptor
IPR001728	Thyroid hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR035500	Nuclear hormone receptor-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001502	cartilage condensation	IMP
biological_process	GO:0001503	ossification	IMP
biological_process	GO:0002155	regulation of thyroid hormone mediated signaling pathway	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0006366	transcription by RNA polymerase II	ISO
biological_process	GO:0007611	learning or memory	IMP
biological_process	GO:0008016	regulation of heart contraction	IMP
biological_process	GO:0008050	female courtship behavior	IMP
biological_process	GO:0009409	response to cold	IMP
biological_process	GO:0009755	hormone-mediated signaling pathway	ISO
biological_process	GO:0009887	animal organ morphogenesis	IMP
biological_process	GO:0010831	positive regulation of myotube differentiation	IDA
biological_process	GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	ISO
biological_process	GO:0030218	erythrocyte differentiation	IMP
biological_process	GO:0030522	intracellular receptor signaling pathway	IEA
biological_process	GO:0030878	thyroid gland development	IGI
biological_process	GO:0033032	regulation of myeloid cell apoptotic process	IMP
biological_process	GO:0042994	cytoplasmic sequestering of transcription factor	IDA
biological_process	GO:0043401	steroid hormone mediated signaling pathway	IEA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0045925	positive regulation of female receptivity	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0050994	regulation of lipid catabolic process	IMP
biological_process	GO:0060509	type I pneumocyte differentiation	IGI
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IC
biological_process	GO:2000143	negative regulation of DNA-templated transcription, initiation	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0002153	steroid receptor RNA activator RNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003707	steroid hormone receptor activity	IEA
molecular_function	GO:0003727	single-stranded RNA binding	IDA
molecular_function	GO:0004879	nuclear receptor activity	IDA
molecular_function	GO:0004887	thyroid hormone receptor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	ISO
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0017025	TBP-class protein binding	ISO
molecular_function	GO:0019904	protein domain specific binding	ISO
molecular_function	GO:0031490	chromatin DNA binding	IDA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0070324	thyroid hormone binding	ISS

Pathways (from Reactome)

Pathway description

Nuclear Receptor transcription pathway

SUMOylation of intracellular receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0000133	abnormal long bone metaphysis morphology	"malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0000422	delayed hair appearance	"late onset of the first appearance of the fur" [J:17792]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0000478	delayed intestine development	"slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0000479	abnormal intestinal cell	"anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000511	abnormal intestinal mucosa morphology	"structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Thra^tm3Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0000872	abnormal external granule cell layer	"malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm3Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mdm2^tm1Bay/Mdm2⁺ Genetic Background: B6.129S7-Mdm2^tm1Bay Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm3Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm3Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm1Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm2Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm3Ven/Thra⁺,Thrb^tm1Df/Thrb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl Allelic Composition: Thra^tm3Ven/Thra⁺,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ddb1^tm1Spg/Ddb1^tm1Spg,Trp53^tm1Tyj/Trp53^tm1Tyj,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
MP:0001290	delayed eyelid opening	"late average time for the first postnatal eye opening" [J:17792]	Show Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0001363	increased anxiety-related response	"when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]	Show Allelic Composition: Thra^tm3Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0001384	abnormal pup retrieval	"a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0001458	abnormal object recognition memory	"defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Thra^tm3Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0001542	abnormal bone strength	"change in the ability of bone to endure the application of force without yielding or breaking" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: a^5R/a^5R Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001629	abnormal heart rate	"greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Inhba^tm1Zuk/Inhba^tm2Zuk Genetic Background: involves: 129S7/SvEvBrd
MP:0001636	irregular heartbeat	"uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]	Show Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0001731	abnormal postnatal growth	"anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm3Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm1Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm3Ven/Thra⁺,Thrb^tm1Df/Thrb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Thra^tm1Jas/Thra⁺,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kitl^sl-blz/Kitl^sl-blz Genetic Background: WSB/EiJ
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mdm2^tm1Bay/Mdm2⁺ Genetic Background: B6.129S7-Mdm2^tm1Bay Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0002188	small heart	"reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0002427	dwarfism	"abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(CAG-cre/Esr1)5Amc/?,Thra^tm1Ffla/Thra⁺ Genetic Background:* involves: 129/Sv * C57BL/6 * CBA
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0002674	abnormal sperm motility	"anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0002710	increased glucagon secretion	"greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0002712	increased circulating glucagon level	"greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002876	abnormal thyroid physiology	"anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003058	increased insulin secretion	"greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0003149	abnormal tectorial membrane morphology	"malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0003233	prolonged QT interval	"increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003312	abnormal locomotor coordination	"reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm3Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0003382	straub tail	"condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0003420	delayed intramembranous bone ossification	"late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003449	abnormal intestinal goblet cells	"malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]	Show Allelic Composition: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003498	thyroid hyperplasia		Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0003499	thyroid hypoplasia		Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003502	increased activity of thyroid		Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003503	decreased activity of thyroid		Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Ven/Thra^tm1Ven Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0003564	abnormal insulin secretion	"aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0003620	decreased urine output	"decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thra^tm2Jas/Thra^tm2Jas Genetic Background: B6.129-Thra^tm2Jas Ncoa1^tm1Bwo
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003795	abnormal bone structure		Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003825	abnormal pillar cell morphology	"abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0003866	abnormal defecation	"anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003953	abnormal hormone level	"aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003965	abnormal pituitary hormone level	"aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0003971	abnormal thyroid-stimulating hormone level		Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004148	increased cortical bone thickness	"thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0004214	abnormal long bone diaphysis morphology	"any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0004359	short ulna	"reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004411	decreased endocochlear potential	"reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004433	abnormal cochlear inner hair cell physiology	"anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004434	abnormal cochlear outer hair cell physiology	"anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004437	decreased cochlear outer hair cell electromotility	"reduced motility of the cochlear OHCs in response to electrical stimulation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004591	enlarged tectorial membrane	"increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004664	delayed inner ear development	"slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0004696	abnormal thyroid follicle morphology	"any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004738	abnormal brainstem auditory evoked potential	"anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0004876	decreased mean arterial blood pressure	"decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0004993	decreased bone resorption	"reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0005119	decreased circulating thyroid-stimulating hormone level	"less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv * C57BL/6
MP:0005122	increased circulating thyroid-stimulating hormone level	"greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thra^tm2Jas/Thra^tm2Jas Genetic Background: B6.129-Thra^tm2Jas Ncoa1^tm1Bwo
MP:0005130	decreased follicle stimulating hormone level	"less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005132	decreased luteinizing hormone level	"lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005135	increased thyroid-stimulating hormone level	"less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0005136	decreased growth hormone level	"less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005138	decreased prolactin level	"less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005361	small pituitary gland	"reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005422	osteosclerosis	"abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0005468	abnormal thyroid hormone level	"aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MP:0005474	increased triiodothyronine level	"greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0005477	increased circulating thyroxine level	"greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thra^tm2Jas/Thra^tm2Jas Genetic Background: B6.129-Thra^tm2Jas Ncoa1^tm1Bwo Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005478	decreased circulating thyroxine level	"less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv * C57BL/6
MP:0005479	decreased circulating triiodothyronine level	"less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005480	increased circulating triiodothyronine level	"greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thra^tm2Jas/Thra^tm2Jas Genetic Background: B6.129-Thra^tm2Jas Ncoa1^tm1Bwo Allelic Composition: Thra^tm4.1Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005533	increased body temperature	"greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005605	increased bone mass	"an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006398	increased long bone epiphyseal plate size	"greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0006399	abnormal long bone epiphyseal ossification zone morphology	"any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0008033	impaired lipolysis	"reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008142	decreased small intestinal villus size	"reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0008151	increased diameter of long bones	"increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0008882	abnormal enterocyte physiology	"any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008883	abnormal enterocyte proliferation	"anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009006	prolonged estrous cycle	"increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J
MP:0009172	small pancreatic islets	"decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0009288	increased epididymal fat pad weight		Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0009347	increased cancellous bone thickness	"thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0009780	abnormal chondrocyte physiology	"any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010122	abnormal bone mineral content	"any anomaly in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010392	prolonged QRS complex duration	"increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010743	delayed suture closure	"late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010878	increased trabecular bone volume	"increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010956	abnormal mitochondrial ATP synthesis coupled electron transport	"anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0010964	increased compact bone volume		Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0010968	decreased compact bone area	"reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0011014	decreased core body temperature	"reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011049	impaired adaptive thermogenesis	"inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Thra^tm3Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Thra^tm1Ffla/Thra⁺,Tg(Sycp1-cre)4Min/? Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Thra^tm2Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺ Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/J
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Thra^tm1Brnt/Thra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Thra^tm1.1Fcas/Thra^tm1.1Fcas Genetic Background: B6.Cg-Thra^tm1.1Fcas
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Thra^tm1Ven/Thra⁺,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0013618	decreased areal bone mineral density	"reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J
MP:0013958	decreased small intestine length	"reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0014082	decreased small intestinal villus height	"decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0014091	abnormal tectorial membrane striated-sheet matrix morphology	"any structural anomaly of the laminated, striated-sheet matrix within which collagen fibrils of the TM are imbedded; the striated sheet matrix is formed by two types of fine-diameter collagen filaments, a light and a dark staining type that lie in parallel within the plane of each sheet and are extensively linked along their length by staggered cross bridges; it originates medially within the sulcal zone, extends to the marginal band and is particularly evident in apical regions of the cochlea, where it has a less compressed appearance" [PMID:18797289, PMID:24363064]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0030020	decreased cardiac cell glucose uptake	"reduced ability of the cells of the heart to take in glucose" [MGI:anna]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0030029	wide cranial sutures	"an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0030388	large fontanelles	"an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ complex / reaction
ENSMUSG00000015120	Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*	/ reaction
ENSMUSG00000020265	Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr