ENSMUSG00000022809


Mus musculus

Features
Gene ID: ENSMUSG00000022809
  
Biological name :Nr1i2
  
Synonyms : Nr1i2 / Nuclear receptor subfamily 1 group I member 2 / O54915
  
Possible biological names infered from orthology : O75469
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 38248323
Gene end: 38294824
  
Corresponding Affymetrix probe sets: 10439411 (MoGene1.0st)   1425723_at (Mouse Genome 430 2.0 Array)   1451807_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023504
NCBI entrez gene - 18171     See in Manteia.
MGI - MGI:1337040
RefSeq - XM_011245840
RefSeq - NM_001098404
RefSeq - NM_010936
RefSeq - XM_006521846
RefSeq - XM_006521847
RefSeq - XM_006521848
RefSeq - XM_011245839
RefSeq Peptide - NP_035066
RefSeq Peptide - NP_001091874
swissprot - O54915
swissprot - Q0P525
Ensembl - ENSMUSG00000022809
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1i2ENSDARG00000029766Danio rerio
 NR1I2ENSG00000144852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vdr / P48281 / vitamin D (1,25-dihydroxyvitamin D3) receptor / P11473* / vitamin D receptor*ENSMUSG0000002247939
Nr1i3 / O35627 / Nuclear receptor subfamily 1 group I member 3 / Q14994*ENSMUSG0000000567736
Thrb / P37242 / Thyroid hormone receptor beta / P10828*ENSMUSG0000002177927
Rara / P11416 / retinoic acid receptor, alpha / P10276*ENSMUSG0000003799227
Rarb / P22605 / retinoic acid receptor, beta / P10826*ENSMUSG0000001749127
Thra / P63058 / Thyroid hormone receptor alpha / P10827*ENSMUSG0000005875627
Nr1h2 / Q60644 / Oxysterols receptor LXR-beta / P55055* / nuclear receptor subfamily 1 group H member 2*ENSMUSG0000006060126
Nr1h3 / Q9Z0Y9 / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133* / nuclear receptor subfamily 1 group H member 3*ENSMUSG0000000210826
Rarg / P18911 / Retinoic acid receptor gamma / P13631*ENSMUSG0000000128825
Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*ENSMUSG0000004763825
Nr1h5ENSMUSG0000004893822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042738 exogenous drug catabolic process IEA
 biological_processGO:0042908 xenobiotic transport IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046618 drug export IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h4tm1.2Auw/Nr1h4tm1.2Auw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tor1atm2Wtd/Tor1atm4.2Wtd
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: SJL.129S4-Ccl2tm1Rol

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte
Genetic Background: involves: C57BL/6

Allelic Composition: Nr1i2tm3Arte/Nr1i2tm3Arte
Genetic Background: involves: C57BL/6

Allelic Composition: Nr1i2tm3Arte/Nr1i2tm3Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

Allelic Composition: Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr