MP:0000182 | increased circulating LDL cholesterol level | "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0000740 | impaired smooth muscle contractility | "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0000820 | abnormal choroid plexus morphology | "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
|
MP:0000822 | abnormal brain ventricle morphology | "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0000823 | abnormal lateral ventricle morphology | "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0000826 | abnormal third ventricle morphology | "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0001119 | abnormal female reproductive anatomy | "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm Genetic Background: involves: 129 * C57BL/6
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MP:0001145 | abnormal male reproductive anatomy | "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm Genetic Background: involves: 129 * C57BL/6
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MP:0001154 | seminiferous tubule degeneration | "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
|
MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002016 | ovarian cysts | "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1Dgen/Nr1h3tm1Dgen Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA
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MP:0002139 | abnormal liver/biliary system physiology | "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Srebf1tm1Mbr/Srebf1tm1Mbr Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm Genetic Background: involves: 129 * C57BL/6
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002446 | abnormal macrophage morphology | "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002608 | increased hematocrit | "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+ Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h3tm1Wexi/Nr1h3tm1Wexi Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0002679 | abnormal corpora lutea | "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002685 | abnormal proliferation of spermatogonia | "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002773 | decreased circulating luteinizing hormone level | "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002780 | decreased circulating testosterone level | "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002784 | abnormal Sertoli cell morphology | "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+ Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
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MP:0002907 | abnormal parturition | "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA
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MP:0003070 | increased vascular permeability | "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003103 | liver degeneration | "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003191 | abnormal cellular cholesterol metabolism | "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0003205 | testicular atrophy | "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
|
MP:0003329 | amyloid beta deposits | |
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Allelic Composition: Nmur2tm1.1Eege/Nmur2tm1.1Eege Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
|
MP:0003507 | abnormal ovary physiology | "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003698 | abnormal male reproductive system physiology | "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003699 | abnormal female reproductive system physiology | "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0003871 | abnormal myelin sheath morphology | "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
|
MP:0004778 | increased foam cell number | "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0004832 | enlarged ovary | "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0004834 | ovary hemorrhage | "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0004950 | abnormal brain vasculature | "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0005182 | increased circulating estradiol level | "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005278 | abnormal cholesterol homeostasis | "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350] |
Show
Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1Dgen/Nr1h3tm1Dgen Genetic Background: Not Specified
Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0005339 | increased susceptibility to atherosclerosis | "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0005343 | increased circulating aspartate transaminase level | "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005365 | abnormal bile salt homeostasis | "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0005537 | abnormal cerebral aqueduct | "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0008028 | pregnancy-related premature death | "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0008256 | abnormal myometrium morphology | "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0008734 | decreased susceptibility to endotoxin shock | "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h3tm1Wexi/Nr1h3tm1Wexi Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA
Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0008934 | absent choroid plexus | "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0009229 | abnormal median eminence morphology | "any structural anomaly of the raised area at the infundibular region of the hypothalamus where the secretions of the hypothalamic neurons (releasing and inhibiting regulatory hormones) collect before entering the capillary network of hypophyseal portal system" [MESH:A06.688.357.500] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0009278 | abnormal bone marrow cell physiology | "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0009648 | abnormal superovulation | "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0009671 | abnormal uterus physiology | "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0009688 | abnormal spinal cord central canal morphology | "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA
Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Nr1h3tm1Djm/Nr1h3tm1Djm,Nus1tm1.1Qrm/Nus1tm1.1Qrm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
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MP:0010152 | abnormal brain ependyma morphology | "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0013218 | abnormal substantia nigra pars reticulata morphology | "any structural anomaly of the anterior (ventral) part of grey matter of the substantia nigra which contains smaller and loosely packed cells than the pars compacta, only some of which contain a small amount of pigment; the cells of pars reticulata bear a strong structural and functional resemblance to the inner segment of the globus pallidus; many cells in this region use GABA as a neurotransmitter" [MGI:anna] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0013598 | Leydig cell hypertrophy | "increased size of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH)" [MGI:Anna] |
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0013908 | small lateral ventricles | "decreased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0013909 | small third ventricle | "decreased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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MP:0013910 | small fourth ventricle | "decreased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith] |
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu Genetic Background: Not Specified
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