ENSDARG00000098439


Danio rerio

Features
Gene ID: ENSDARG00000098439
  
Biological name :nr1h3
  
Synonyms : nr1h3 / nuclear receptor subfamily 1, group H, member 3
  
Possible biological names infered from orthology : Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133 / Q9Z0Y9
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 34414194
Gene end: 34448076
  
Corresponding Affymetrix probe sets: Dr.22152.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000137180
Ensembl peptide - ENSDARP00000151701
Ensembl peptide - ENSDARP00000139970
NCBI entrez gene - 548341     See in Manteia.
RefSeq - NM_001017545
RefSeq Peptide - NP_001017545
swissprot - A1L1Z8
swissprot - A0A0R4IVP0
swissprot - Q56A56
ZFIN ID - ZDB-GENE-050410-7
Ensembl - ENSDARG00000098439
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR1H3ENSGALG00000038059Gallus gallus
 NR1H3ENSG00000025434Homo sapiens
 Nr1h3ENSMUSG00000002108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr1h4 / nuclear receptor subfamily 1, group H, member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSDARG0000005774134
rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000003489329
raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000005678329
vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*ENSDARG0000007072128
rarga / Q91392 / retinoic acid receptor gamma a / RARG* / P18911* / P13631* / retinoic acid receptor gamma*ENSDARG0000003411728
rargb / retinoic acid receptor, gamma b / RARG* / P13631* / retinoic acid receptor gamma*ENSDARG0000005400328
nr1h5 / nuclear receptor subfamily 1, group H, member 5ENSDARG0000003104627
thrb / Q9PVE4 / thyroid hormone receptor beta / P10828* / P37242*ENSDARG0000002116326
thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000005265426
thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000000015126
nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*ENSDARG0000002976624
vdra / vitamin D receptor a / VDR* / P11473* / vitamin D receptor*ENSDARG0000009948318
CABZ01088036.1 / VDR* / P11473* / vitamin D receptor*ENSDARG0000011292312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR023257  Liver X receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage shape , abnormal
Meckels cartilage circular , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage curved , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction






 

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