ENSGALG00000038059


Gallus gallus

Features
Gene ID: ENSGALG00000038059
  
Biological name :NR1H3
  
Synonyms : NR1H3 / nuclear receptor subfamily 1 group H member 3
  
Possible biological names infered from orthology : Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133 / Q9Z0Y9
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 23115970
Gene end: 23143954
  
Corresponding Affymetrix probe sets: Gga.4130.1.S1_at (Chicken Array)   Gga.4130.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055522
NCBI entrez gene - 395221     See in Manteia.
RefSeq - XM_015286920
RefSeq - NM_204542
RefSeq - XM_015286918
RefSeq - XM_015286919
RefSeq - XM_015286916
RefSeq - XM_015286917
RefSeq Peptide - NP_989873
swissprot - Q8JHU1
Ensembl - ENSGALG00000038059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1h3ENSDARG00000098439Danio rerio
 NR1H3ENSG00000025434Homo sapiens
 Nr1h3ENSMUSG00000002108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSGALG0000001159436
Nr1h5*ENSGALG0000000217036
RARB / P22448 / Retinoic acid receptor beta / P10826* / P22605*ENSGALG0000001129831
RARA / retinoic acid receptor alpha / P10276* / P11416*ENSGALG0000003793530
THRB / P68306 / Thyroid hormone receptor beta / P10828* / P37242*ENSGALG0000001129428
THRA / Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA. / P10827* / P63058* / thyroid hormone receptor, alpha*ENSGALG0000004001727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR023257  Liver X receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0010887 negative regulation of cholesterol storage IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043031 negative regulation of macrophage activation IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0044255 cellular lipid metabolic process IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0055092 sterol homeostasis IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IEA
 biological_processGO:0090341 negative regulation of secretion of lysosomal enzymes IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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