ENSGALG00000037935


Gallus gallus

Features
Gene ID: ENSGALG00000037935
  
Biological name :RARA
  
Synonyms : RARA / retinoic acid receptor alpha
  
Possible biological names infered from orthology : P10276 / P11416
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 4830348
Gene end: 4836063
  
Corresponding Affymetrix probe sets: Gga.112.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047963
Ensembl peptide - ENSGALP00000062385
NCBI entrez gene - 395213     See in Manteia.
RefSeq - NM_204536
RefSeq Peptide - NP_989867
swissprot - A0A1L1RU93
swissprot - A0A1D5P5J4
Ensembl - ENSGALG00000037935
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 raraaENSDARG00000056783Danio rerio
 rarabENSDARG00000034893Danio rerio
 RARAENSG00000131759Homo sapiens
 RaraENSMUSG00000037992Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RARB / P22448 / Retinoic acid receptor beta / P10826* / P22605*ENSGALG0000001129869
THRA / Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA. / P10827* / P63058* / thyroid hormone receptor, alpha*ENSGALG0000004001728
THRB / P68306 / Thyroid hormone receptor beta / P10828* / P37242*ENSGALG0000001129427
NR1H3 / nuclear receptor subfamily 1 group H member 3 / Q13133* / Q9Z0Y9* / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA.*ENSGALG0000003805926
NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSGALG0000001159423
Nr1h5*ENSGALG0000000217022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003078  Retinoic acid receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002068 glandular epithelial cell development IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003417 growth plate cartilage development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030852 regulation of granulocyte differentiation IEA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IEA
 biological_processGO:0031076 embryonic camera-type eye development IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032736 positive regulation of interleukin-13 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045947 negative regulation of translational initiation IEA
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 biological_processGO:0051099 positive regulation of binding IEA
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IEA
 biological_processGO:0060010 Sertoli cell fate commitment IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060534 trachea cartilage development IEA
 biological_processGO:0060591 chondroblast differentiation IEA
 biological_processGO:0061037 negative regulation of cartilage development IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003708 retinoic acid receptor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044323 retinoic acid-responsive element binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051018 protein kinase A binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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