ENSGALG00000011294


Gallus gallus

Features
Gene ID: ENSGALG00000011294
  
Biological name :THRB
  
Synonyms : P68306 / THRB / Thyroid hormone receptor beta
  
Possible biological names infered from orthology : P10828 / P37242
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 37403149
Gene end: 37554300
  
Corresponding Affymetrix probe sets: Gga.609.1.S1_at (Chicken Array)   Gga.699.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050545
Ensembl peptide - ENSGALP00000060050
Ensembl peptide - ENSGALP00000018401
Ensembl peptide - ENSGALP00000018402
Ensembl peptide - ENSGALP00000030526
NCBI entrez gene - 396431     See in Manteia.
RefSeq - XM_015281326
RefSeq - NM_001252221
RefSeq - NM_205447
RefSeq - XM_015281323
RefSeq - XM_015281324
RefSeq - XM_015281325
RefSeq Peptide - NP_990778
RefSeq Peptide - NP_001239150
swissprot - A0A1I7Q415
swissprot - F1NWE9
swissprot - P68306
swissprot - A0A1D5PCQ4
Ensembl - ENSGALG00000011294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thrbENSDARG00000021163Danio rerio
 THRBENSG00000151090Homo sapiens
 ThrbENSMUSG00000021779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THRA / Gallus gallus thyroid hormone receptor, alpha (THRA), mRNA. / P10827* / P63058* / thyroid hormone receptor, alpha*ENSGALG0000004001769
RARB / P22448 / Retinoic acid receptor beta / P10826* / P22605*ENSGALG0000001129827
RARA / retinoic acid receptor alpha / P10276* / P11416*ENSGALG0000003793527
Nr1h5*ENSGALG0000000217026
NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSGALG0000001159425
NR1H3 / nuclear receptor subfamily 1 group H member 3 / Q13133* / Q9Z0Y9* / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA.*ENSGALG0000003805924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007621 negative regulation of female receptivity IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0008050 female courtship behavior IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060509 type I pneumocyte differentiation IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070324 thyroid hormone binding IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IDA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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