ENSDARG00000021163


Danio rerio

Features
Gene ID: ENSDARG00000021163
  
Biological name :thrb
  
Synonyms : Q9PVE4 / thrb / thyroid hormone receptor beta
  
Possible biological names infered from orthology : P10828 / P37242
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 17514631
Gene end: 17658253
  
Corresponding Affymetrix probe sets: Dr.8125.1.S1_at (Zebrafish Array)   DrAffx.2.26.A1_at (Zebrafish Array)   DrAffx.2.26.S1_at (Zebrafish Array)   DrAffx.2.26.S1_s_at (Zebrafish Array)   NM_131340_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000152213
Ensembl peptide - ENSDARP00000152808
Ensembl peptide - ENSDARP00000022899
Ensembl peptide - ENSDARP00000126275
Ensembl peptide - ENSDARP00000131464
Ensembl peptide - ENSDARP00000137456
Ensembl peptide - ENSDARP00000144469
Ensembl peptide - ENSDARP00000149633
Ensembl peptide - ENSDARP00000150484
NCBI entrez gene - 30607     See in Manteia.
RefSeq - NM_131340
RefSeq Peptide - NP_571415
swissprot - J9JI02
swissprot - A0A0R4IEJ5
swissprot - Q9PVE4
swissprot - S6BPQ3
ZFIN ID - ZDB-GENE-990415-268
Ensembl - ENSDARG00000021163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 THRBENSGALG00000011294Gallus gallus
 THRBENSG00000151090Homo sapiens
 ThrbENSMUSG00000021779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000005265462
thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000000015161
raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000005678326
rarga / Q91392 / retinoic acid receptor gamma a / RARG* / P18911* / P13631* / retinoic acid receptor gamma*ENSDARG0000003411726
rargb / retinoic acid receptor, gamma b / RARG* / P13631* / retinoic acid receptor gamma*ENSDARG0000005400325
rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000003489325
nr1h4 / nuclear receptor subfamily 1, group H, member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSDARG0000005774124
vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*ENSDARG0000007072123
nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*ENSDARG0000009843922
nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*ENSDARG0000002976621
nr1h5 / nuclear receptor subfamily 1, group H, member 5ENSDARG0000003104619
CABZ01088036.1 / VDR* / P11473* / vitamin D receptor*ENSDARG0000011292312
vdra / vitamin D receptor a / VDR* / P11473* / vitamin D receptor*ENSDARG0000009948311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002154 thyroid hormone mediated signaling pathway IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0048839 inner ear development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070324 thyroid hormone binding ISS


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
Show

 ZFA:0000107 eye eye decreased pigmentation , abnormal
Show

 ZFA:0000118 hypophysis hypophysis increased amount , abnormal
hypophysis increased distribution , abnormal
hypophysis cell increased volume , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
Show

 ZFA:0000152 retina retina disorganized , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle increased amount , abnormal
thyroid follicle hyperplastic , abnormal
thyroid follicle increased distribution , abnormal
thyroid follicle cell increased amount , abnormal
thyroid follicle cell increased volume , abnormal
thyroid follicle increased size , abnormal
Show

 ZFA:0001081 thyroid primordium thyroid primordium increased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism lacks parts or has fewer parts of type pectoral fin , abnormal
whole organism has extra parts of type thyroid follicle , abnormal
whole organism dead , abnormal
whole organism lacks parts or has fewer parts of type semicircular canal , abnormal
whole organism lacks parts or has fewer parts of type otolith , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton has fewer parts of type cartilage element , abnormal
Show

 ZFA:0009221 UV sensitive photoreceptor cell UV sensitive photoreceptor cell increased amount , abnormal
Show

 ZFA:0009315 horizontal cell horizontal cell synapse increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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