ENSDARG00000057741


Danio rerio

Features
Gene ID: ENSDARG00000057741
  
Biological name :nr1h4
  
Synonyms : nr1h4 / nuclear receptor subfamily 1, group H, member 4
  
Possible biological names infered from orthology : Bile acid receptor / Q60641 / Q96RI1
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 15644559
Gene end: 15666942
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000061793
NCBI entrez gene - 436847     See in Manteia.
RefSeq - NM_001002574
RefSeq Peptide - NP_001002574
swissprot - Q568N6
ZFIN ID - ZDB-GENE-040718-313
Ensembl - ENSDARG00000057741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR1H4ENSGALG00000011594Gallus gallus
 NR1H4ENSG00000012504Homo sapiens
 Nr1h4ENSMUSG00000047638Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr1h5 / nuclear receptor subfamily 1, group H, member 5ENSDARG0000003104636
nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*ENSDARG0000009843931
vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*ENSDARG0000007072127
thrb / Q9PVE4 / thyroid hormone receptor beta / P10828* / P37242*ENSDARG0000002116326
rarga / Q91392 / retinoic acid receptor gamma a / RARG* / P18911* / P13631* / retinoic acid receptor gamma*ENSDARG0000003411724
thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000005265424
rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000003489323
thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000000015123
raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000005678323
rargb / retinoic acid receptor, gamma b / RARG* / P13631* / retinoic acid receptor gamma*ENSDARG0000005400323
nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*ENSDARG0000002976621
vdra / vitamin D receptor a / VDR* / P11473* / vitamin D receptor*ENSDARG0000009948314
CABZ01088036.1 / VDR* / P11473* / vitamin D receptor*ENSDARG0000011292312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0032052 bile acid binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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