ENSDARG00000000151


Danio rerio

Features
Gene ID: ENSDARG00000000151
  
Biological name :thraa
  
Synonyms : Q98867 / thraa / thyroid hormone receptor alpha a
  
Possible biological names infered from orthology : P10827 / P63058 / THRA / thyroid hormone receptor, alpha
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 34688022
Gene end: 34753605
  
Corresponding Affymetrix probe sets: Dr.454.1.S1_at (Zebrafish Array)   NM_131396_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000000160
Ensembl peptide - ENSDARP00000125835
Ensembl peptide - ENSDARP00000143608
NCBI entrez gene - 30670     See in Manteia.
RefSeq - NM_131396
RefSeq Peptide - NP_571471
swissprot - I3ISF8
swissprot - B2GQG7
swissprot - Q98867
ZFIN ID - ZDB-GENE-990415-263
Ensembl - ENSDARG00000000151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 THRAENSGALG00000040017Gallus gallus
 THRAENSG00000126351Homo sapiens
 ThraENSMUSG00000058756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*ENSDARG0000005265487
thrb / Q9PVE4 / thyroid hormone receptor beta / P10828* / P37242*ENSDARG0000002116373
rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000003489331
raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*ENSDARG0000005678331
rarga / Q91392 / retinoic acid receptor gamma a / RARG* / P18911* / P13631* / retinoic acid receptor gamma*ENSDARG0000003411731
rargb / retinoic acid receptor, gamma b / RARG* / P13631* / retinoic acid receptor gamma*ENSDARG0000005400330
vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*ENSDARG0000007072126
nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*ENSDARG0000009843926
nr1h4 / nuclear receptor subfamily 1, group H, member 4 / Q60641* / Q96RI1* / Bile acid receptor *ENSDARG0000005774126
nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*ENSDARG0000002976625
nr1h5 / nuclear receptor subfamily 1, group H, member 5ENSDARG0000003104621
vdra / vitamin D receptor a / VDR* / P11473* / vitamin D receptor*ENSDARG0000009948313
CABZ01088036.1 / VDR* / P11473* / vitamin D receptor*ENSDARG0000011292313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002154 thyroid hormone mediated signaling pathway IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
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 ZFA:0000118 hypophysis hypophysis cell decreased volume , abnormal
hypophysis increased amount , abnormal
hypophysis increased distribution , abnormal
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 ZFA:0000150 pronephric duct pronephric duct decreased amount , abnormal
pronephric duct proximal region absent , abnormal
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 ZFA:0000345 dorsal rectus dorsal rectus morphology , abnormal
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 ZFA:0000457 ventral rectus ventral rectus morphology , abnormal
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 ZFA:0000640 cornea cornea lacks parts or has fewer parts of type corneal endothelium , abnormal
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 ZFA:0000738 dorsal oblique extraocular muscle dorsal oblique extraocular muscle morphology , abnormal
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 ZFA:0000861 ventral oblique extraocular muscle ventral oblique extraocular muscle morphology , abnormal
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 ZFA:0001072 thyroid follicle thyroid follicle decreased distribution , abnormal
thyroid follicle cell decreased volume , abnormal
thyroid follicle decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism decreased amount , abnormal
whole organism decreased pigmentation , abnormal
whole organism increased amount , abnormal
whole organism lacks parts or has fewer parts of type pectoral fin , abnormal
whole organism has fewer parts of type thyroid follicle , abnormal
whole organism dead , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage malformed , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton has fewer parts of type cartilage element , abnormal
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 ZFA:0001261 ventricular system ventricular system edematous , abnormal
ventricular system hydrocephalic , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch decreased amount , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage malformed , abnormal
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 ZFA:0001683 corneal epithelium corneal epithelium increased thickness , abnormal
corneal epithelium scalloped , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction






 

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