ENSMUSG00000047638


Mus musculus

Features
Gene ID: ENSMUSG00000047638
  
Biological name :Nr1h4
  
Synonyms : Bile acid receptor / Nr1h4 / Q60641
  
Possible biological names infered from orthology : nuclear receptor subfamily 1 group H member 4 / Q96RI1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 89454234
Gene end: 89533585
  
Corresponding Affymetrix probe sets: 10371784 (MoGene1.0st)   1419105_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053092
Ensembl peptide - ENSMUSP00000100933
Ensembl peptide - ENSMUSP00000100934
NCBI entrez gene - 20186     See in Manteia.
MGI - MGI:1352464
RefSeq - XM_006513393
RefSeq - NM_001163504
RefSeq - NM_001163700
RefSeq - NM_009108
RefSeq - XM_006513391
RefSeq Peptide - NP_033134
RefSeq Peptide - NP_001156976
RefSeq Peptide - NP_001157172
swissprot - Q3V1T8
swissprot - Q60641
Ensembl - ENSMUSG00000047638
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1h4ENSDARG00000057741Danio rerio
 NR1H4ENSGALG00000011594Gallus gallus
 NR1H4ENSG00000012504Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr1h5ENSMUSG0000004893842
Nr1h3 / Q9Z0Y9 / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133* / nuclear receptor subfamily 1 group H member 3*ENSMUSG0000000210830
Nr1h2 / Q60644 / Oxysterols receptor LXR-beta / P55055* / nuclear receptor subfamily 1 group H member 2*ENSMUSG0000006060130
Thrb / P37242 / Thyroid hormone receptor beta / P10828*ENSMUSG0000002177925
Rarb / P22605 / retinoic acid receptor, beta / P10826*ENSMUSG0000001749124
Vdr / P48281 / vitamin D (1,25-dihydroxyvitamin D3) receptor / P11473* / vitamin D receptor*ENSMUSG0000002247924
Thra / P63058 / Thyroid hormone receptor alpha / P10827*ENSMUSG0000005875623
Rara / P11416 / retinoic acid receptor, alpha / P10276*ENSMUSG0000003799223
Rarg / P18911 / Retinoic acid receptor gamma / P13631*ENSMUSG0000000128823
Nr1i2 / O54915 / Nuclear receptor subfamily 1 group I member 2 / O75469*ENSMUSG0000002280922
Nr1i3 / O35627 / Nuclear receptor subfamily 1 group I member 3 / Q14994*ENSMUSG0000000567722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter IC
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0008206 bile acid metabolic process IMP
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0010988 regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032692 negative regulation of interleukin-1 production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IMP
 biological_processGO:0034255 regulation of urea metabolic process IMP
 biological_processGO:0034971 histone H3-R17 methylation IEA
 biological_processGO:0035356 cellular triglyceride homeostasis IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0038183 bile acid signaling pathway IMP
 biological_processGO:0038185 intracellular bile acid receptor signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IDA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0055089 fatty acid homeostasis IMP
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070328 triglyceride homeostasis IDA
 biological_processGO:0070858 negative regulation of bile acid biosynthetic process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071417 cellular response to organonitrogen compound IMP
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0072615 interleukin-17 secretion IEA
 biological_processGO:1902714 negative regulation of interferon-gamma secretion IEA
 biological_processGO:1904179 positive regulation of adipose tissue development IMP
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905695 positive regulation of phosphatidic acid biosynthetic process IEA
 biological_processGO:2000213 positive regulation of glutamate metabolic process IMP
 biological_processGO:2001250 positive regulation of ammonia assimilation cycle IMP
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IGI
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0032052 bile acid binding IMP
 molecular_functionGO:0038181 bile acid receptor activity IC
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IDA
 molecular_functionGO:1902122 chenodeoxycholic acid binding IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: either: B6.Cg-Plcg1tm1Gcrp/Plcg1tm1Rwen Tg(Cd4-cre)1Cwi or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: STOCK Nr1h4tm1Gonz/J

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: STOCK Nr1h4tm1Gonz/J

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.2Auw/Nr1h4tm1.2Auw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.2Auw/Nr1h4tm1.2Auw
Genetic Background: involves: 129 * C57BL/6J

 MP:0003980 increased circulating phospholipid level "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nr1h4tm1.2Auw/Nr1h4tm1.2Auw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: STOCK Nr1h4tm1Gonz/J

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: STOCK Nr1h4tm1Gonz/J

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008988 abnormal liver perisinusoidal space morphology "any structural anomaly of the extravascular space in the liver between the parenchymal cells and a sinusoid that contains the blood plasma" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009342 enlarged gall bladder "increased size of the gall bladder, the organ that serves as a storage reservoir for bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009476 enlarged cecum "increased size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj
Genetic Background: B6N.B6-Nr1h4tm1.1Mbj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005886 Ncoa2 / Q61026 / Nuclear receptor coactivator 2 / Q15596*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020647 Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*  / complex / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / reaction / complex






 

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