Manteia - Molecule gene

ENSMUSG00000015846

Mus musculus

Features

Gene ID:	ENSMUSG00000015846

Biological name :	Rxra

Synonyms :	P28700 / retinoid X receptor alpha / Rxra

Possible biological names infered from orthology :	P19793

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	A3
Gene start:	27676440
Gene end:	27762957

Corresponding Affymetrix probe sets:	10470446 (MoGene1.0st) 1425762_a_at (Mouse Genome 430 2.0 Array) 1430497_at (Mouse Genome 430 2.0 Array) 1454773_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000076491 Ensembl peptide - ENSMUSP00000109567 Ensembl peptide - ENSMUSP00000115165 Ensembl peptide - ENSMUSP00000133044 Ensembl peptide - ENSMUSP00000097822 NCBI entrez gene - 20181 See in Manteia. MGI - MGI:98214 RefSeq - XM_006497805 RefSeq - NM_001290481 RefSeq - NM_001290482 RefSeq - NM_011305 RefSeq Peptide - NP_035435 RefSeq Peptide - NP_001277410 RefSeq Peptide - NP_001277411 swissprot - A2AJP1 swissprot - A2AJP2 swissprot - P28700 swissprot - Q6LC96 Ensembl - ENSMUSG00000015846

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rxraa	ENSDARG00000057737	Danio rerio
rxrab	ENSDARG00000035127	Danio rerio
RXRA	ENSGALG00000042055	Gallus gallus
RXRA	ENSG00000186350	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*	ENSMUSG00000015843	70
Rxrb / P28704 / retinoid X receptor beta / P28702*	ENSMUSG00000039656	69
Nr2f2 / P43135 / nuclear receptor subfamily 2, group F, member 2 / P24468*	ENSMUSG00000030551	34
Nr2f1 / nuclear receptor subfamily 2, group F, member 1 / P10589*	ENSMUSG00000069171	34
Hnf4g / hepatocyte nuclear factor 4 gamma / Q14541*	ENSMUSG00000017688	32
Nr2f6 / P43136 / Nuclear receptor subfamily 2 group F member 6 / P10588*	ENSMUSG00000002393	32
Hnf4a / P49698 / Hepatocyte nuclear factor 4-alpha / P41235*	ENSMUSG00000017950	32
Nr2c2 / P49117 / nuclear receptor subfamily 2, group C, member 2 / P49116*	ENSMUSG00000005893	31
Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*	ENSMUSG00000005897	30
Nr2e3 / Q9QXZ7 / Photoreceptor-specific nuclear receptor / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*	ENSMUSG00000032292	30
Nr2e1 / Q64104 / nuclear receptor subfamily 2, group E, member 1 / Q9Y466*	ENSMUSG00000019803	27

Protein motifs (from Interpro)

Interpro ID	Name
IPR000003	Retinoid X receptor/HNF4
IPR000536	Nuclear hormone receptor, ligand-binding domain
IPR001628	Zinc finger, nuclear hormone receptor-type
IPR001723	Nuclear hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR021780	Nuclear/hormone receptor activator site AF-1
IPR035500	Nuclear hormone receptor-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0001701	in utero embryonic development	IGI
biological_process	GO:0001890	placenta development	IMP
biological_process	GO:0001893	maternal placenta development	IGI
biological_process	GO:0003007	heart morphogenesis	TAS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IDA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IGI
biological_process	GO:0007507	heart development	TAS
biological_process	GO:0007566	embryo implantation	IGI
biological_process	GO:0010629	negative regulation of gene expression	TAS
biological_process	GO:0019048	modulation by virus of host morphology or physiology	ISO
biological_process	GO:0032526	response to retinoic acid	ISO
biological_process	GO:0035357	peroxisome proliferator activated receptor signaling pathway	ISO
biological_process	GO:0043010	camera-type eye development	IGI
biological_process	GO:0043401	steroid hormone mediated signaling pathway	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	TAS
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0045994	positive regulation of translational initiation by iron	IGI
biological_process	GO:0048384	retinoic acid receptor signaling pathway	ISO
biological_process	GO:0051289	protein homotetramerization	ISO
biological_process	GO:0055007	cardiac muscle cell differentiation	TAS
biological_process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP
biological_process	GO:0055012	ventricular cardiac muscle cell differentiation	IMP
biological_process	GO:0060038	cardiac muscle cell proliferation	TAS
biological_process	GO:0060485	mesenchyme development	TAS
biological_process	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP
biological_process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	IMP
biological_process	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	TAS
biological_process	GO:0061032	visceral serous pericardium development	TAS
biological_process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IDA
cellular_component	GO:0000790	nuclear chromatin	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:0043235	receptor complex	ISO
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	IDA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0001972	retinoic acid binding	ISO
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0003690	double-stranded DNA binding	ISO
molecular_function	GO:0003700	DNA-binding transcription factor activity	ISO
molecular_function	GO:0003707	steroid hormone receptor activity	IEA
molecular_function	GO:0004879	nuclear receptor activity	ISO
molecular_function	GO:0004886	9-cis retinoic acid receptor activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IPI
molecular_function	GO:0008270	zinc ion binding	ISO
molecular_function	GO:0016922	nuclear receptor binding	ISO
molecular_function	GO:0019899	enzyme binding	ISO
molecular_function	GO:0031490	chromatin DNA binding	IDA
molecular_function	GO:0042277	peptide binding	ISO
molecular_function	GO:0042809	vitamin D receptor binding	ISO
molecular_function	GO:0043565	sequence-specific DNA binding	ISO
molecular_function	GO:0044212	transcription regulatory region DNA binding	IDA
molecular_function	GO:0044323	retinoic acid-responsive element binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	ISO
molecular_function	GO:0050692	DBD domain binding	ISO
molecular_function	GO:0050693	LBD domain binding	ISO
molecular_function	GO:0070644	vitamin D response element binding	ISO

Pathways (from Reactome)

Pathway description

Recycling of bile acids and salts

Synthesis of bile acids and bile salts

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Import of palmitoyl-CoA into the mitochondrial matrix

Regulation of pyruvate dehydrogenase (PDH) complex

Endogenous sterols

Transcriptional regulation of white adipocyte differentiation

Nuclear Receptor transcription pathway

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

SUMOylation of intracellular receptors

Signaling by Retinoic Acid

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000279	ventricular hypoplasia	"reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Tg(Myh6-Rxra)41Pcn/0 Genetic Background: involves: 129S2/SvPas
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000286	abnormal mitral valve morphology	"malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000288	abnormal pericardium morphology	"malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000295	poorly developed ventricular trabeculae	"retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000297	abnormal endocardial cushion morphology	"malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000299	failure of endocardial cushion closure	"failure of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices" [J:29971]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000371	diluted coat color	"a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000384	distorted hair follicle pattern	"twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000389	disorganized outer root sheath cells	"disordered enveloping layer of cells of the hair follicle; surrounds inner root and is continuous with basal and spinous layers of the epidermis" [J:56777]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000422	delayed hair appearance	"late onset of the first appearance of the fur" [J:17792]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000597	delayed hepatic development	"late onset of the induction and/or differentiation of the liver" [J:18048]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Foxq1^sa-e1/Foxq1^sa-e1 Genetic Background: involves: 101/Rl * C3H/Rl
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0001167	prostate epithelial hyperplasia	"epithelium is multi-layered instead of columnar with increased cell number" [J:63764]	Show Allelic Composition: Erbb2^{tm3(Erbb2)Mul}/Erbb2^{tm3(Erbb2)Mul} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001191	abnormal skin condition	"anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0001196	shiny skin	"skin with a glossy or glistening appearance" [J:56641]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001201	translucent skin	"skin that is more transparent to light than normal " [J:15108]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0001240	abnormal cornified layer morphology	"structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001245	thick dermal layer	"increased depth of the dermis" [J:65033]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001246	mixed cellular infiltration to dermis	"gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0001247	dermal cysts	"abnormal membranous sacs appearing in the dermis" [J:53379]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Rxra^tm2Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129/Sv Allelic Composition: Rxra^tm4.1Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001327	reduced retinal photoreceptor cell number	"fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001622	abnormal vasculogenesis	"aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129/Sv Allelic Composition: Rxra^tm4.1Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001711	abnormal placenta		Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac
MP:0001716	abnormal placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129/Sv Allelic Composition: Rxra^tm4.1Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001798	impaired macrophage phagocytosis	"reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001849	ear inflammation	"local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm4.1Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129S2/SvPas
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm2Ipc Genetic Background: involves: 129/Sv
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm2Ipc Genetic Background: involves: 129/Sv
MP:0002089	abnormal postnatal growth/weight/body size	"increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Rxra^tm2Ipc/Rxra^tm2Ipc Genetic Background: involves: 129/Sv
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0002127	abnormal cardiovascular system morphology	"abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Rxra^tm2Ipc/Rxra^tm2Ipc Genetic Background: involves: 129/Sv
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myl2^tm1(cre)Krc/Myl2⁺,Rxra^tm1Krc/Rxra^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss
MP:0002189	abnormal myocardial trabeculae morphology	"malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002258	abnormal cricoid cartilage morphology	"any structural anomaly of the most inferior of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm2Ipc Genetic Background: involves: 129/Sv
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxq1^sa-e1/Foxq1^sa-e1 Genetic Background: involves: 101/Rl * C3H/Rl
MP:0002376	abnormal dendritic cell physiology	"failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J
MP:0002434	abnormal T helper 2 morphology/development	"anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002624	abnormal tricuspid valve morphology	"malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002655	abnormal keratinocyte morphology	"structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0002672	abnormal branchial arch artery morphology	"malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002745	abnormal atrioventricular valve morphology	"malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002754	dilated right ventricle	"an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002864	abnormal ocular fundus morphology	"malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003011	delayed dark adaptation	"increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003140	dilated atria	"an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003393	decreased cardiac output	"reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003413	hair follicle degeneration	"a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0003607	abnormal prostate physiology	"malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Erbb2^{tm3(Erbb2)Mul}/Erbb2^{tm3(Erbb2)Mul} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129/Sv Allelic Composition: Rxra^tm4.1Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129S2/SvPas
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003729	abnormal photoreceptor outer segments	"malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003731	abnormal outer nuclear layer morphology	"malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003853	dry skin	"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0003881	abnormal nephron morphology	"malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003923	abnormal left atrium morphology	"structural anomaly of the left upper chamber of the heart " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003983	decreased cholesterol level	"less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc,Rxrb^tm1Pcn/Rxrb^tm1Pcn,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0004001	decreased hepatocyte proliferation	"reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004021	abnormal rod electrophysiology	"anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004022	abnormal cone electrophysiology	"anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004056	abnormal myocardial compact layer morphology	"malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004058	abnormal ventricular papillary muscle morphology	"structural anomaly of one of the group of myocardial bundles which terrminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004126	thin hypodermis	"reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004771	increased anti-single stranded DNA antibody level	"increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004946	abnormal regulatory T cell physiology	"any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grhl3^ct-J/Grhl3^ct-J,mct1^C57BL/6J/mct1^C57BL/6J Genetic Background: involves: BALB/cByJ * STOCK ct/J
MP:0004947	skin inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0004971	dermal hyperplasia	"overdevelopment or increased size, usually due an increased number of cells in the dermal layer of the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc,Rxrb^tm1Mma/Rxrb^tm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: 129S2/SvPas
MP:0005075	abnormal melanosome morphology	"anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005193	abnormal anterior eye segment morphology	"anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Taf4^tm1Idvd/Taf4^tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Rarg^tm2Ipc/Rarg^tm2Ipc,Rxra^tm2Ipc/Rxra^tm2Ipc Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0005201	abnormal retinal pigment epithelium morphology	"anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005300	abnormal corneal stroma morphology	"structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005548	retinal pigment epithelium atrophy	"wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0006119	mitral valve atresia	"congenital closure of the mitral valve" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006122	mitral valve stenosis	"abnormal narrowing of the mitral valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1.1Krc/Rxra^tm1.1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss
MP:0008059	abnormal podocyte foot process morphology	"any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008117	abnormal Langerhans cell morphology	"any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0008139	fused podocyte foot processes	"coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008244	abnormal peritoneal macrophage morphology	"any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008259	abnormal optic disc morphology	"any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac
MP:0008586	disorganized photoreceptor outer segment	"derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008587	short photoreceptor outer segment	"decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^Rgsc702/Gck^Rgsc702 Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008858	abnormal hair cycle anagen phase	"anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0008860	abnormal hair cycle telogen phase	"anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and preceeds hair loss" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0008881	absent Harderian gland	"absence of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [MESH:A13.445]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac
MP:0009219	prostate intraepithelial neoplasia	"noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Erbb2^{tm3(Erbb2)Mul}/Erbb2^{tm3(Erbb2)Mul} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0009555	abnormal hair follicle melanin granule distribution	"anomaly in the spatial arrangement of particles produced by melanocytes that confer color in the hair follicle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0009583	increased keratinocyte proliferation	"increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0009612	thick epidermis suprabasal layer		Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0009736	abnormal prostate gland branching morphogenesis	"anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Erbb2^{tm3(Erbb2)Mul}/Erbb2^{tm3(Erbb2)Mul} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0010064	increased circulating creatine level	"increase in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010454	abnormal truncus arteriosis septation	"anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010455	aortopulmonary window	"a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries" [http://emedicine.medscape.com]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010457	pulmonary artery stenosis	"constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Rev/Rxra⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010519	atrioventricular block	"a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010559	heart block	"a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010584	abnormal conotruncus septation	"anomaly in the process in which the conotruncus separates into the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0010585	abnormal conotruncal ridge morphology	"any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010640	ventricular myocardium compact layer hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0010706	ventral rotation of lens	"a circular shift toward the ventral pole in the position of the equator of the lens relative to the optic nerve exit point" [PMID:7923367]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0010707	decreased ventral retina size	"decreasd size of the ventral portion of the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:7923367]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0010710	absent sclera	"absence of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea" [MESH:A09.371.784]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0010711	persistent hyperplastic primary vitreous	"persistence of the embryonic fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0010716	coloboma of the optic disc	"congenital defect of the optic disc in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0010720	absent sublingual duct	"absence of the canals that drain the sublingual gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0011075	abnormal macrophage activation involved in immune response	"anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa Genetic Background: involves: 129S7/SvEvBrd
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rxra^tm1.1Krc/Rxra^tm1.1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm2Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129/Sv Allelic Composition: Rxra^tm4.1Ipc/Rxra^tm4.1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Tg(Myh6-Rxra)41Pcn/0 Genetic Background: involves: 129S2/SvPas
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Rxra^tm1.1Pcn/Rxra^tm1.1Pcn Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0011294	renal glomerulus hypertrophy	"increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011353	expanded mesangial matrix	"increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011369	increased renal glomerulus apoptosis	"increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011409	increased renal glomerulus basement membrane thickness	"increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Rxra^tm1Krc/Rxra^tm1Krc,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0012501	abnormal pericardial cavity morphology	"any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]	Show Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0012802	increased rhombomere 5 size	"increased size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order " [MGI:anna]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0013269	third pharyngeal arch hypoplasia	"underdevelopment or reduced size of the third pharyngeal arch, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0030335	absent third pharyngeal arch artery	"failure to develop or absence of the third pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc,Rxrb^tm1Mma/Rxrb^tm1Mma Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0030570	abnormal piliary canal morphology	"any structural anomaly of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft" [PMID:19211055, UBERON:0035610]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0030571	dilated piliary canal	"stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [MGI:anna, PMID:11171393]	Show Allelic Composition: Rxra^tm2Ipc/Rxra^tm4Ipc,Tg(KRT14-cre)1Ipc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000002250	Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*	/ complex
ENSMUSG00000005886	Ncoa2 / Q61026 / Nuclear receptor coactivator 2 / Q15596*	/ reaction / complex
ENSMUSG00000027533	Fabp5 / Q05816 / Fatty acid-binding protein, epidermal / Q01469* / fatty acid binding protein 5*	/ complex / reaction
ENSMUSG00000027630	Q8BHJ5 / Tbl1xr1 / F-box-like/WD repeat-containing protein TBL1XR1 / Q9BZK7* / transducin beta like 1 X-linked receptor 1*	/ reaction / complex
ENSMUSG00000022383	Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*	/ reaction / complex
ENSMUSG00000037992	Rara / P11416 / retinoic acid receptor, alpha / P10276*	/ complex
ENSMUSG00000015120	Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*	/ reaction
ENSMUSG00000001288	Rarg / P18911 / Retinoic acid receptor gamma / P13631*	/ complex
ENSMUSG00000054422	Fabp1 / P12710 / Fatty acid-binding protein, liver / P07148* / fatty acid binding protein 1*	/ reaction
ENSMUSG00000047638	Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*	/ reaction / complex
ENSMUSG00000000440	Pparg / peroxisome proliferator activated receptor gamma / P37231*	/ complex / reaction
ENSMUSG00000004885	Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*	/ complex / reaction
ENSMUSG00000029478	Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*	/ reaction / complex
ENSMUSG00000020647	Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*	/ complex / reaction
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ reaction / complex
ENSMUSG00000017491	Rarb / P22605 / retinoic acid receptor, beta / P10826*	/ complex
ENSMUSG00000025246	Tbl1x / Q9QXE7 / F-box-like/WD repeat-containing protein TBL1X / TBL1Y* / Q9BQ87* / O60907* / transducin beta like 1 X-linked* / transducin beta like 1 Y-linked*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr