ENSMUSG00000025246


Mus musculus

Features
Gene ID: ENSMUSG00000025246
  
Biological name :Tbl1x
  
Synonyms : F-box-like/WD repeat-containing protein TBL1X / Q9QXE7 / Tbl1x
  
Possible biological names infered from orthology : O60907 / Q9BQ87 / TBL1Y / transducin beta like 1 X-linked / transducin beta like 1 Y-linked
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: B
Gene start: 77511013
Gene end: 77662983
  
Corresponding Affymetrix probe sets: 10600547 (MoGene1.0st)   1434643_at (Mouse Genome 430 2.0 Array)   1434644_at (Mouse Genome 430 2.0 Array)   1455042_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085549
NCBI entrez gene - 21372     See in Manteia.
MGI - MGI:1336172
RefSeq - NM_020601
RefSeq - XM_006527939
RefSeq Peptide - NP_065626
swissprot - Q9QXE7
Ensembl - ENSMUSG00000025246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbl1xENSDARG00000060438Danio rerio
 TBL1XENSGALG00000040006Gallus gallus
 TBL1XENSG00000101849Homo sapiens
 TBL1YENSG00000092377Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BHJ5 / Tbl1xr1 / F-box-like/WD repeat-containing protein TBL1XR1 / Q9BZK7* / transducin beta like 1 X-linked receptor 1*ENSMUSG0000002763087
Thoc3 / Q8VE80 / THO complex subunit 3 / Q96J01* / THO complex 3*ENSMUSG0000002587215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006594  LIS1 homology motif
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043627 response to estrogen IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048545 response to steroid hormone IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0000118 histone deacetylase complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005876 spindle microtubule ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027630 Q8BHJ5 / Tbl1xr1 / F-box-like/WD repeat-containing protein TBL1XR1 / Q9BZK7* / transducin beta like 1 X-linked receptor 1*  / reaction / complex
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction
 ENSMUSG00000054422 Fabp1 / P12710 / Fatty acid-binding protein, liver / P07148* / fatty acid binding protein 1*  / reaction
 ENSMUSG00000022383 Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr