ENSMUSG00000022383


Mus musculus

Features
Gene ID: ENSMUSG00000022383
  
Biological name :Ppara
  
Synonyms : P23204 / peroxisome proliferator activated receptor alpha / Ppara
  
Possible biological names infered from orthology : Q07869
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E2
Gene start: 85734983
Gene end: 85802819
  
Corresponding Affymetrix probe sets: 10425987 (MoGene1.0st)   1439675_at (Mouse Genome 430 2.0 Array)   1449051_at (Mouse Genome 430 2.0 Array)   1457721_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059719
Ensembl peptide - ENSMUSP00000105049
Ensembl peptide - ENSMUSP00000105050
NCBI entrez gene - 19013     See in Manteia.
MGI - MGI:104740
RefSeq - XM_011245519
RefSeq - NM_001113418
RefSeq - NM_011144
RefSeq - XM_006520623
RefSeq - XM_006520624
RefSeq - XM_011245516
RefSeq - XM_011245517
RefSeq - XM_006520619
RefSeq - XM_006520620
RefSeq - XM_006520621
RefSeq - XM_006520622
RefSeq Peptide - NP_035274
RefSeq Peptide - NP_001106889
swissprot - P23204
swissprot - Q542P9
Ensembl - ENSMUSG00000022383
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pparaaENSDARG00000031777Danio rerio
 pparabENSDARG00000054323Danio rerio
 PPARAENSGALG00000041470Gallus gallus
 PPARAENSG00000186951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*ENSMUSG0000000225058
Pparg / peroxisome proliferator activated receptor gamma / P37231*ENSMUSG0000000044055
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*ENSMUSG0000002177529
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088928
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223825
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*ENSMUSG0000002815023
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*ENSMUSG0000003619222
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*ENSMUSG0000002639818
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397218
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003074  Peroxisome proliferator-activated receptor
 IPR003076  Peroxisome proliferator-activated receptor alpha
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006631 fatty acid metabolic process TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation ISO
 biological_processGO:0010871 negative regulation of receptor biosynthetic process ISO
 biological_processGO:0010887 negative regulation of cholesterol storage ISO
 biological_processGO:0010891 negative regulation of sequestering of triglyceride ISO
 biological_processGO:0019217 regulation of fatty acid metabolic process IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032099 negative regulation of appetite IMP
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042752 regulation of circadian rhythm IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IMP
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046321 positive regulation of fatty acid oxidation IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050728 negative regulation of inflammatory response ISO
 biological_processGO:0070166 enamel mineralization IMP
 biological_processGO:0072363 regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter ISO
 biological_processGO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter ISO
 biological_processGO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter ISO
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1903038 negative regulation of leukocyte cell-cell adhesion ISO
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISO
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0004879 nuclear receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0008144 drug binding ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity TAS
 molecular_functionGO:0051525 NFAT protein binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000184 abnormal circulating HDL cholesterol level "anomalous concentration in the blood of high denisty lipoprotein; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: B6.129S4-Pparatm1Gonz

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: B6.129S4-Pparatm1Gonz

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: B6.129S4-Pparatm1Gonz

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: B6.129S4-Pparatm1Gonz

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0003457 abnormal circulating ketone body level "aberrant amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: B6.129S4-Pparatm1Gonz

 MP:0009598 thin epidermis stratum granulosum "decreased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0009605 decreased keratohyalin granule number "reduced number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Daxxtm1Led/Daxxtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: 129S4/SvJae-Pparatm1Gonz

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027630 Q8BHJ5 / Tbl1xr1 / F-box-like/WD repeat-containing protein TBL1XR1 / Q9BZK7* / transducin beta like 1 X-linked receptor 1*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction
 ENSMUSG00000054422 Fabp1 / P12710 / Fatty acid-binding protein, liver / P07148* / fatty acid binding protein 1*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000025246 Tbl1x / Q9QXE7 / F-box-like/WD repeat-containing protein TBL1X / TBL1Y* / Q9BQ87* / O60907* / transducin beta like 1 X-linked* / transducin beta like 1 Y-linked*  / complex / reaction






 

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