ENSMUSG00000036192


Mus musculus

Features
Gene ID: ENSMUSG00000036192
  
Biological name :Rorb
  
Synonyms : Nuclear receptor ROR-beta / Q8R1B8 / Rorb
  
Possible biological names infered from orthology : Q92753 / RAR related orphan receptor B
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: B
Gene start: 18930605
Gene end: 19111196
  
Corresponding Affymetrix probe sets: 10466587 (MoGene1.0st)   1425162_at (Mouse Genome 430 2.0 Array)   1439862_at (Mouse Genome 430 2.0 Array)   1455799_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047597
Ensembl peptide - ENSMUSP00000108447
Ensembl peptide - ENSMUSP00000108451
NCBI entrez gene - 225998     See in Manteia.
MGI - MGI:1343464
RefSeq - NM_001043354
RefSeq - NM_001289921
RefSeq - NM_146095
RefSeq Peptide - NP_001036819
RefSeq Peptide - NP_001276850
RefSeq Peptide - NP_666207
swissprot - Q8R1B8
swissprot - A0A0R4J1H4
Ensembl - ENSMUSG00000036192
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rorbENSDARG00000033498Danio rerio
 RORBENSGALG00000015150Gallus gallus
 RORBENSG00000198963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223863
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*ENSMUSG0000002815050
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*ENSMUSG0000002177529
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088928
Pparg / peroxisome proliferator activated receptor gamma / P37231*ENSMUSG0000000044022
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*ENSMUSG0000000225022
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*ENSMUSG0000002238322
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*ENSMUSG0000002639820
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675120
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397218


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003079  Nuclear receptor ROR
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046548 retinal rod cell development IMP
 biological_processGO:0046549 retinal cone cell development IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0071300 cellular response to retinoic acid ISS
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbm3Btlr/Rorbm3Btlr
Genetic Background: C57BL/6J-Rorbm3Btlr

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Rac2m1Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m1Btlr

Allelic Composition: Rorbm3Btlr/Rorbm3Btlr
Genetic Background: C57BL/6J-Rorbm3Btlr

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Red/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0002983 increased retinal ganglion cell number "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0006095 absent amacrine cells "absence or loss of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:74753]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008107 absent horizontal cells "absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0008445 increased retinal cone cell number "greater number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm2.1Df/Rorbtm2.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm2.1Df/Rorbtm2.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008454 absent retinal rod cells "absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008520 disorganized retinal outer plexiform layer "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0008583 absent photoreceptor inner segment "absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbtm1.1Df/Rorbtm1.1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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