ENSMUSG00000021775


Mus musculus

Features
Gene ID: ENSMUSG00000021775
  
Biological name :Nr1d2
  
Synonyms : Nr1d2 / nuclear receptor subfamily 1, group D, member 2 / Q60674
  
Possible biological names infered from orthology : Q14995
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A2
Gene start: 18204054
Gene end: 18239127
  
Corresponding Affymetrix probe sets: 10417734 (MoGene1.0st)   1416958_at (Mouse Genome 430 2.0 Array)   1416959_at (Mouse Genome 430 2.0 Array)   1457250_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153325
Ensembl peptide - ENSMUSP00000088031
NCBI entrez gene - 353187     See in Manteia.
MGI - MGI:2449205
RefSeq - NM_011584
RefSeq Peptide - NP_035714
swissprot - A0A286YD98
swissprot - Q4VAB7
swissprot - Q60674
Ensembl - ENSMUSG00000021775
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1d2bENSDARG00000009594Danio rerio
 NR1D2ENSGALG00000011291Gallus gallus
 NR1D2ENSG00000174738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088952
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223825
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*ENSMUSG0000002815025
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*ENSMUSG0000002238324
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*ENSMUSG0000000225023
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*ENSMUSG0000003619223
Pparg / peroxisome proliferator activated receptor gamma / P37231*ENSMUSG0000000044022
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*ENSMUSG0000002639820
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397219
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042752 regulation of circadian rhythm IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0055088 lipid homeostasis IMP
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Nr1d1tm1.2Rev/Nr1d1tm1.2Rev
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nr1d2tm1Dgen/Nr1d2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1d1tm1.2Rev/Nr1d1tm1.2Rev
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1d1tm1.2Rev/Nr1d1tm1.2Rev
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1d1tm1.2Rev/Nr1d1tm1.2Rev
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0010419 inlet ventricular septal defect "abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves" [http://emedicine.medscape.com]
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Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

Allelic Composition: Nr1d2tm1Dgen/Nr1d2+
Genetic Background: B6;129P2-Nr1d2tm1Dgen/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nr1d2tm1Dgen/Nr1d2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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