ENSMUSG00000026398


Mus musculus

Features
Gene ID: ENSMUSG00000026398
  
Biological name :Nr5a2
  
Synonyms : Nr5a2 / Nuclear receptor subfamily 5 group A member 2 / P45448
  
Possible biological names infered from orthology : O00482
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 136842571
Gene end: 136960448
  
Corresponding Affymetrix probe sets: 10358210 (MoGene1.0st)   1420410_at (Mouse Genome 430 2.0 Array)   1449706_s_at (Mouse Genome 430 2.0 Array)   1449707_at (Mouse Genome 430 2.0 Array)   1456521_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141645
Ensembl peptide - ENSMUSP00000142219
Ensembl peptide - ENSMUSP00000027649
Ensembl peptide - ENSMUSP00000129071
Ensembl peptide - ENSMUSP00000141495
NCBI entrez gene - 26424     See in Manteia.
MGI - MGI:1346834
RefSeq - XM_006529622
RefSeq - XM_006529621
RefSeq - NM_001159769
RefSeq - NM_030676
RefSeq Peptide - NP_109601
RefSeq Peptide - NP_001153241
swissprot - P45448
swissprot - Q1WLP7
swissprot - A0A0A6YY04
swissprot - A0A0A6YWQ4
Ensembl - ENSMUSG00000026398
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr5a2ENSDARG00000100940Danio rerio
 NR5A2ENSGALG00000002182Gallus gallus
 NR5A2ENSG00000116833Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675149
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*ENSMUSG0000002177521
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088921
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397219
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223817
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*ENSMUSG0000003619217
Pparg / peroxisome proliferator activated receptor gamma / P37231*ENSMUSG0000000044017
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*ENSMUSG0000002815016
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*ENSMUSG0000000225015
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*ENSMUSG0000002238315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016355  Nuclear hormone receptor family 5
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008206 bile acid metabolic process IMP
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0061113 pancreas morphogenesis IMP
 biological_processGO:0097720 calcineurin-mediated signaling IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm1Sjns/Nr5a2tm1Sjns,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Nr5a2tm1Auw/Nr5a2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr5a2tm1Auw/Nr5a2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001652 colonic necrosis "pathologic death of cells within, or a portion of, the colon" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr5a2tm1Auw/Nr5a2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rdh5tm1Drie/Rdh5tm1Drie
Genetic Background: Not Specified

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Nr5a2tm1Auw/Nr5a2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm1Sjns/Nr5a2tm1Sjns,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr5a2tm1Auw/Nr5a2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0012142 absent amniotic cavity "absence of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0012224 abnormal sterol level "anomaly in the level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [MGI:csmith]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm1Sjns/Nr5a2tm1Sjns,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000027678 Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000052056 Zfp217 / zinc finger protein 217 / O75362* / ZNF217*  / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex






 

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