Manteia - Molecule gene

ENSMUSG00000063972

Mus musculus

Features

Gene ID:	ENSMUSG00000063972

Biological name :	Nr6a1

Synonyms :	Nr6a1 / Nuclear receptor subfamily 6 group A member 1 / Q64249

Possible biological names infered from orthology :	Q15406

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	B
Gene start:	38723370
Gene end:	38927688

Corresponding Affymetrix probe sets:	10482249 (MoGene1.0st) 1421515_at (Mouse Genome 430 2.0 Array) 1421516_at (Mouse Genome 430 2.0 Array) 1428825_at (Mouse Genome 430 2.0 Array) 1428826_at (Mouse Genome 430 2.0 Array) 1445872_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000108498 Ensembl peptide - ENSMUSP00000121234 Ensembl peptide - ENSMUSP00000126009 Ensembl peptide - ENSMUSP00000075624 Ensembl peptide - ENSMUSP00000115164 NCBI entrez gene - 14536 See in Manteia. MGI - MGI:1352459 RefSeq - NM_001159548 RefSeq - NM_001159549 RefSeq - NM_010264 RefSeq - XM_011239025 RefSeq Peptide - NP_001153020 RefSeq Peptide - NP_001153021 RefSeq Peptide - NP_034394 swissprot - A0A0A0MQG4 swissprot - Q64249 swissprot - Z4YMW4 Ensembl - ENSMUSG00000063972

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nr6a1a	ENSDARG00000101508	Danio rerio
NR6A1	ENSGALG00000001073	Gallus gallus
NR6A1	ENSG00000148200	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*	ENSMUSG00000026398	22
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*	ENSMUSG00000021775	22
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*	ENSMUSG00000020889	20
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*	ENSMUSG00000028150	18
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*	ENSMUSG00000026751	18
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*	ENSMUSG00000032238	18
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*	ENSMUSG00000022383	17
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*	ENSMUSG00000036192	17
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*	ENSMUSG00000002250	17
Pparg / peroxisome proliferator activated receptor gamma / P37231*	ENSMUSG00000000440	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR000536	Nuclear hormone receptor, ligand-binding domain
IPR001628	Zinc finger, nuclear hormone receptor-type
IPR001723	Nuclear hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR035500	Nuclear hormone receptor-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007276	gamete generation	IEP
biological_process	GO:0007283	spermatogenesis	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030518	intracellular steroid hormone receptor signaling pathway	IBA
biological_process	GO:0043401	steroid hormone mediated signaling pathway	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005667	transcription factor complex	IDA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IMP
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IMP
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003707	steroid hormone receptor activity	IEA
molecular_function	GO:0004879	nuclear receptor activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IDA
molecular_function	GO:0043565	sequence-specific DNA binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Nuclear Receptor transcription pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0000288	abnormal pericardium morphology	"malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0000292	distended pericardial sacs	"stretched outer parietal layer of the pericardium" [J:25248]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001056	abnormal cranial nerve morphology	"any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001061	abnormal oculomotor nerve morphology	"malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001063	abnormal trochlear nerve morphology	"any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001125	abnormal oocytes	"anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0001289	persistence of hyaloid capillary system	"failure of the degeneration of the transient vascular system of the eye during development" [J:49840]	Show Allelic Composition: Npc1^{tm1b(EUCOMM)Hmgu}/Npc1⁺ Genetic Background: C57BL/6N-Npc1^{tm1b(EUCOMM)Hmgu}/H
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tyr^c-15R145M/Tyr^c Genetic Background: involves: 101/Rl * C3H/Rl Allelic Composition: Nr6a1^{Gt(RRA042)Byg}/Nr6a1^{Gt(RRA042)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr6a1^{tm1d(EUCOMM)Wtsi}/Nr6a1^{tm1d(EUCOMM)Wtsi} Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * SJL Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001689	incomplete somite formation	"arrest of differentiation or patterning of the somites" [J:62882]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001691	abnormal somite shape	"atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Nr6a1^{tm1d(EUCOMM)Wtsi}/Nr6a1^{tm1d(EUCOMM)Wtsi} Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * SJL
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001701	incomplete embryo turning	"arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]	Show Allelic Composition: Nr6a1^{tm1d(EUCOMM)Wtsi}/Nr6a1^{tm1d(EUCOMM)Wtsi} Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * SJL
MP:0001718	abnormal yolk sac	"malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001722	pale yolk sac	"bloodless yolk sac" [J:62571]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001726	abnormal allantois	"malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0002231	abnormal primitive streak morphology	"anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0002790	decreased circulating follicle stimulating hormone level	"less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0002824	abnormal chorioallantoic fusion	"abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0002836	abnormal chorion	"malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002861	abnormal tail bud morphology	"anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0003384	abnormal ventral body wall	"malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003425	abnormal optic vesicle formation	"anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0003864	abnormal midbrain development	"anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0004073	caudal body truncation	"caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004174	abnormal spine curvature	"deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004180	failure of initiation of embryo turning	"failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004556	enlarged allantois	"increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0005185	decreased circulating progesterone level	"less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0006108	abnormal hindbrain development	"anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0008786	abnormal hindgut morphology	"any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009006	prolonged estrous cycle	"increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0009010	abnormal diestrus	"any anomaly or aberrant timing of the last phase of the estrous cycle, during which unfertilized eggs are eliminated, the vagina and vulva are at a minimum size, and new follicles begin to undergo a rapid growth for the next ovulation; if pregnancy does not occur, the metestrous phase is ultimately followed by the diestrous phase" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0009011	prolonged diestrus	"increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0009433	polyovular ovarian follicle	"an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺,Tg(Fabp1-cre)1Mmt/? Genetic Background: involves: 129X1/SvJ
MP:0009657	failure of chorioallantoic fusion	"failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009768	impaired somite development	"atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr6a1^{tm1d(EUCOMM)Wtsi}/Nr6a1^{tm1d(EUCOMM)Wtsi} Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * SJL
MP:0010378	increased respiratory quotient	"increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^{tm1b(EUCOMM)Hmgu}/Npc1⁺ Genetic Background: C57BL/6N-Npc1^{tm1b(EUCOMM)Hmgu}/H
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Nr6a1^{Gt(RRA042)Byg}/Nr6a1^{Gt(RRA042)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr6a1^{tm1d(EUCOMM)Wtsi}/Nr6a1^{tm1d(EUCOMM)Wtsi} Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * SJL
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay
MP:0012086	absent hindgut	"absence of the caudal portion of the primitive digestive tube of the embryo" [MGI:anna]	Show Allelic Composition: Mapk8ip3^tm1.1Ysok/Mapk8ip3^tm1.1Ysok Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012544	abnormal caudal neuropore morphology	"any structural anomaly of the temporary opening at the extreme caudal end of the neural tube in early embryos; the posterior neuropore appears before the process of neural tube closure is complete" [MGI:anna]	Show Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Nr6a1^{tm1b(EUCOMM)Wtsi}/Nr6a1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nr6a1^{tm1b(EUCOMM)Wtsi}/Bay

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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