ENSMUSG00000002250


Mus musculus

Features
Gene ID: ENSMUSG00000002250
  
Biological name :Ppard
  
Synonyms : P35396 / Peroxisome proliferator-activated receptor delta / Ppard
  
Possible biological names infered from orthology : Q03181
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 28232754
Gene end: 28301469
  
Corresponding Affymetrix probe sets: 10443332 (MoGene1.0st)   1425703_at (Mouse Genome 430 2.0 Array)   1439797_at (Mouse Genome 430 2.0 Array)   1447902_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133077
Ensembl peptide - ENSMUSP00000002320
NCBI entrez gene - 19015     See in Manteia.
MGI - MGI:101884
RefSeq - NM_011145
RefSeq Peptide - NP_035275
swissprot - E9PV57
swissprot - P35396
swissprot - Q546I3
Ensembl - ENSMUSG00000002250
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppardaENSDARG00000044525Danio rerio
 ppardbENSDARG00000009473Danio rerio
 PPARDENSGALG00000002588Gallus gallus
 PPARDENSG00000112033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*ENSMUSG0000002238362
Pparg / peroxisome proliferator activated receptor gamma / P37231*ENSMUSG0000000044057
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*ENSMUSG0000002177530
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088929
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*ENSMUSG0000002815026
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223825
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*ENSMUSG0000003619224
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397219
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*ENSMUSG0000002639819
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003074  Peroxisome proliferator-activated receptor
 IPR003075  Peroxisome proliferator-activated receptor, beta
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006029 proteoglycan metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEP
 biological_processGO:0006776 vitamin A metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008366 axon ensheathment IMP
 biological_processGO:0008544 epidermis development TAS
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009299 mRNA transcription IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009987 cellular process TAS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IMP
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0015908 fatty acid transport IEP
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031589 cell-substrate adhesion IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043415 positive regulation of skeletal muscle tissue regeneration IMP
 biological_processGO:0043616 keratinocyte proliferation IMP
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045684 positive regulation of epidermis development IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IGI
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050796 regulation of insulin secretion NAS
 biological_processGO:0051546 keratinocyte migration IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071456 cellular response to hypoxia IGI
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:2000288 positive regulation of myoblast proliferation IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016501 prostacyclin receptor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding TAS
 molecular_functionGO:0046982 protein heterodimerization activity TAS
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0070539 linoleic acid binding IEA


Pathways (from Reactome)
Pathway description
Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: ApcMin/Apc+,Ppardtm1Jps/Ppardtm1Jps
Genetic Background: involves: 129/Sv * AKR/J * C57BL/6 * C57BL/6J

 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004126 thin hypodermis "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: ApcMin/Apc+,Ppardtm1Jps/Ppardtm1Jps
Genetic Background: involves: 129/Sv * AKR/J * C57BL/6 * C57BL/6J

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0009287 decreased abdominal fat pad weight "less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0009596 abnormal stratum corneum lipid matrix formation "altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0010963 abnormal compact bone volume "any anomaly in the amount of space occupied by compact bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ppardtm1Dsvg/Ppardtm1Dsvg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: Not Specified

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0012735 abnormal response to exercise "any anomaly in the physiological changes induced by controlled exercise" [MPD:Molly]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0013383 increased sebaceous gland adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period" [MGI:Anna]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013639 decreased bone stiffness "decrease in material stiffness (N/mm) during elastic deformation" [MGI:jwhite]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0013646 decreased energy dissipated prior to femur fracture "decrease in the fraction of total energy dissapated prior to ultimate material failure (high energy fracture) by the femur" [MGI:jwhite]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0030009 increased bone marrow adipose tissue amount "increased quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0030576 abnormal keratinocyte adhesion "any anomaly in the adhesive properties of keratinocytes, resulting in abnormal cell to cell and cell to extracellular matrix (ECM) interactions" [MGI:anna]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0030583 abnormal hair follicle peg morphology "any structural anomaly of the solid column of keratinocytes growing into the dermis during embryonic hair follicle development; the concave proximal end starts to encase the dermal condensate, the future dermal papilla" [UBERON:0035611]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex
 ENSMUSG00000027533 Fabp5 / Q05816 / Fatty acid-binding protein, epidermal / Q01469* / fatty acid binding protein 5*  / complex / reaction






 

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