ENSMUSG00000000440


Mus musculus

Features
Gene ID: ENSMUSG00000000440
  
Biological name :Pparg
  
Synonyms : peroxisome proliferator activated receptor gamma / Pparg
  
Possible biological names infered from orthology : P37231
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 115360951
Gene end: 115490399
  
Corresponding Affymetrix probe sets: 10540897 (MoGene1.0st)   1420715_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000450
Ensembl peptide - ENSMUSP00000144975
Ensembl peptide - ENSMUSP00000145083
Ensembl peptide - ENSMUSP00000145525
Ensembl peptide - ENSMUSP00000131962
NCBI entrez gene - 19016     See in Manteia.
MGI - MGI:97747
RefSeq - XM_017321456
RefSeq - NM_001308354
RefSeq - NM_011146
RefSeq - XM_006505737
RefSeq - XM_006505738
RefSeq - XM_006505739
RefSeq - XM_006505743
RefSeq - XM_011241252
RefSeq - XM_017321455
RefSeq - NM_001127330
RefSeq - NM_001308352
RefSeq Peptide - NP_001295283
RefSeq Peptide - NP_035276
RefSeq Peptide - NP_001120802
RefSeq Peptide - NP_001295281
swissprot - Q6GU14
swissprot - A0A0N4SVF8
swissprot - M1VPI1
swissprot - A0A0N4SV67
Ensembl - ENSMUSG00000000440
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPARGENSGALG00000004974Gallus gallus
 PPARGENSG00000132170Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*ENSMUSG0000002238351
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*ENSMUSG0000000225050
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088926
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*ENSMUSG0000002177526
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223823
Rorc / P51450 / Nuclear receptor ROR-gamma / P51449* / RAR related orphan receptor C*ENSMUSG0000002815022
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*ENSMUSG0000003619220
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*ENSMUSG0000002639819
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675116
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003074  Peroxisome proliferator-activated receptor
 IPR003077  Peroxisome proliferator-activated receptor gamma
 IPR013088  Zinc finger, NHR/GATA-type
 IPR022590  Peroxisome proliferator-activated receptor gamma, N-terminal
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002674 negative regulation of acute inflammatory response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010742 macrophage derived foam cell differentiation IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010871 negative regulation of receptor biosynthetic process IEA
 biological_processGO:0010887 negative regulation of cholesterol storage IEA
 biological_processGO:0010891 negative regulation of sequestering of triglyceride IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0035357 peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0042953 lipoprotein transport IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045598 regulation of fat cell differentiation IEA
 biological_processGO:0045713 low-density lipoprotein particle receptor biosynthetic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046321 positive regulation of fatty acid oxidation IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051974 negative regulation of telomerase activity IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060965 negative regulation of gene silencing by miRNA IEA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071306 cellular response to vitamin E IEA
 biological_processGO:0071379 cellular response to prostaglandin stimulus IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:1901558 response to metformin IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IEA
 biological_processGO:1905563 negative regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000230 negative regulation of pancreatic stellate cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050692 DBD domain binding IEA
 molecular_functionGO:0050693 LBD domain binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000175 absent bone marrow cell "lack of cells that make up the core cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Tyrc-8FrS/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Dmrtc2tm1.1Zark/Dmrtc2tm1.1Zark,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: involves: 129S1/SvImJ

 MP:0000649 sebaceous gland atrophy "wasting or decreased size of holocrine glands of the dermis that secrete sebum into the hair follicles" [J:65146]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Pparg+
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001490 abnormal vibrissae reflex "animals do not change position in response to stimulation of the whiskers" [J:17194]
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Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0001599 abnormal blood volume "anomalous amount of space occupied by the blood in the vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Emx2tm1Sia/Emx2tm1Sia,Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6 * CBA

 MP:0001711 abnormal placenta 
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm1Uls/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001781 abnormal white fat amount "anomaly in the quantity of the fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mettm2Cbm/Mettm2.1Cbm,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tpi1a-M4Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Lhb-cre)1Sac/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001993 abnormal blinking 
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm
Genetic Background: 129P2/OlaHsd-Aprttm1Dwm

Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpi1a-M4Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpi1a-M4Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpi1a-M4Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002596 abnormal hematocrit "greater or less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Lhb-cre)1Sac/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Unc/Ppargtm1.1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Unc/Ppargtm1.1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ppargtm1.1Unc/Pparg+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003157 impaired muscle relaxation "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003846 matted coat "coat hairs sticks together to form clumps and does not lie flat" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)12Flv/?
Genetic Background: B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005133 increased luteinizing hormone level "higher than normal levels of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Lhb-cre)1Sac/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpi1a-M4Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm1.1Unc/Ppargtm1.1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0005346 abnormal circulating aldosterone level "anomalous blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

 MP:0006080 CNS ischemia "abnormal incidence of or response to loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/ApcMin,Rr27tm1Rohl/Rr27+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006274 abnormal urine sodium level "any change in the level of excretion of sodium in the urine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008244 abnormal peritoneal macrophage morphology "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0,Tg(tetO-HIST1H2BJ/GFP)47Efu/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008541 leukostasis "abnormal intravascular leukocyte aggregation and clumping most commonly seen in the brain and lungs of organisms with leukemia" [MESH:C15.378.553.560]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008861 abnormal hair shedding "anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009010 abnormal diestrus "any anomaly or aberrant timing of the last phase of the estrous cycle, during which unfertilized eggs are eliminated, the vagina and vulva are at a minimum size, and new follicles begin to undergo a rapid growth for the next ovulation; if pregnancy does not occur, the metestrous phase is ultimately followed by the diestrous phase" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Lhb-cre)1Sac/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009110 pancreas hyperplasia "overdevelopment or increased size of the pancreas, usually due an increased number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009119 increased brown fat cell size "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009128 decreased brown fat cell number "reduction in the number of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009132 abnormal white fat cell size "anomaly in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009135 abnormal brown fat cell size "anomaly in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Ppargtm3(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Ppargtm2(tTA)Yba/Pparg+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009535 abnormal skin sebaceous gland morphology "any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Uls/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010064 increased circulating creatine level "increase in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0010678 abnormal skin adnexa morphology "any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Krt1-15-cre/PGR)22Cot/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010964 increased compact bone volume 
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm
Genetic Background: 129P2/OlaHsd-Aprttm1Dwm

Allelic Composition: Ppargtm1Mae/Ppargtm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppargtm1Uls/Ppargtm1Uls
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Emx2tm1Sia/Emx2tm1Sia,Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

Allelic Composition: Ppargtm1Tka/Ppargtm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011442 abnormal renal sodium ion transport "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0012126 abnormal placenta hemotrichorial membrane morphology "any structural anomaly of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses" [MGI:anna]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ppargtm1Lja/Pparg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction






 

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