ENSMUSG00000028150


Mus musculus

Features
Gene ID: ENSMUSG00000028150
  
Biological name :Rorc
  
Synonyms : Nuclear receptor ROR-gamma / P51450 / Rorc
  
Possible biological names infered from orthology : P51449 / RAR related orphan receptor C
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 94372794
Gene end: 94398276
  
Corresponding Affymetrix probe sets: 10494023 (MoGene1.0st)   1425792_a_at (Mouse Genome 430 2.0 Array)   1425793_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143763
Ensembl peptide - ENSMUSP00000029795
Ensembl peptide - ENSMUSP00000143610
NCBI entrez gene - 19885     See in Manteia.
MGI - MGI:104856
RefSeq - XM_006501163
RefSeq - NM_001293734
RefSeq - NM_011281
RefSeq - XM_006501162
RefSeq Peptide - NP_001280663
RefSeq Peptide - NP_035411
swissprot - A0A0R4J096
swissprot - P51450
swissprot - A0A0G2JGZ6
Ensembl - ENSMUSG00000028150
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rorcENSDARG00000087195Danio rerio
 RORCENSGALG00000033941Gallus gallus
 RORCENSG00000143365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*ENSMUSG0000003223848
Rorb / Q8R1B8 / Nuclear receptor ROR-beta / Q92753* / RAR related orphan receptor B*ENSMUSG0000003619246
Nr1d2 / Q60674 / nuclear receptor subfamily 1, group D, member 2 / Q14995*ENSMUSG0000002177528
Nr1d1 / Q3UV55 / Nuclear receptor subfamily 1 group D member 1 / P20393*ENSMUSG0000002088926
Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*ENSMUSG0000000225022
Pparg / peroxisome proliferator activated receptor gamma / P37231*ENSMUSG0000000044021
Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*ENSMUSG0000002238321
Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSMUSG0000002675118
Nr6a1 / Q64249 / Nuclear receptor subfamily 6 group A member 1 / Q15406*ENSMUSG0000006397218
Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*ENSMUSG0000002639818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003079  Nuclear receptor ROR
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006805 xenobiotic metabolic process IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0019218 regulation of steroid metabolic process IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032620 interleukin-17 production IDA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0036315 cellular response to sterol ISO
 biological_processGO:0042753 positive regulation of circadian rhythm IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045586 regulation of gamma-delta T cell differentiation IDA
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046632 alpha-beta T cell differentiation IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0048537 mucosal-associated lymphoid tissue development IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0072539 T-helper 17 cell differentiation IDA
 biological_processGO:0072615 interleukin-17 secretion IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008142 oxysterol binding ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Nfiatm1Rmg/Nfia+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001652 colonic necrosis "pathologic death of cells within, or a portion of, the colon" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfiatm1Rmg/Nfia+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1m1Btlr/Rc3h1+
Genetic Background: C57BL/6J-Rc3h1m1Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfiatm1Rmg/Nfia+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

Allelic Composition: Rorcm1Btlr/Rorcm1Btlr
Genetic Background: C57BL/6J-Rorcm1Btlr

Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

Allelic Composition: Rorcm1Btlr/Rorcm1Btlr
Genetic Background: C57BL/6J-Rorcm1Btlr

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0008400 abnormal CD4-positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD4-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009624 small inguinal lymph nodes "reduced size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: Rorcm3Btlr/Rorcm3Btlr
Genetic Background: C57BL/6J-Rorcm3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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