ENSMUSG00000027533


Mus musculus

Features
Gene ID: ENSMUSG00000027533
  
Biological name :Fabp5
  
Synonyms : Fabp5 / Fatty acid-binding protein, epidermal / Q05816
  
Possible biological names infered from orthology : fatty acid binding protein 5 / Q01469
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A1
Gene start: 10012548
Gene end: 10016607
  
Corresponding Affymetrix probe sets: 10490838 (MoGene1.0st)   10585699 (MoGene1.0st)   1416021_a_at (Mouse Genome 430 2.0 Array)   1416022_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029046
NCBI entrez gene - 16592     See in Manteia.
MGI - MGI:101790
RefSeq - NM_010634
RefSeq - NM_001272097
RefSeq - NM_001272098
RefSeq Peptide - NP_001259026
RefSeq Peptide - NP_001259027
RefSeq Peptide - NP_034764
swissprot - Q05816
swissprot - Q497I3
Ensembl - ENSMUSG00000027533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01088982.1ENSDARG00000109259Danio rerio
 fabp11aENSDARG00000017299Danio rerio
 fabp11bENSDARG00000002311Danio rerio
 FABP5ENSGALG00000041344Gallus gallus
 FABP5ENSG00000164687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fabp4 / P04117 / Fatty acid-binding protein, adipocyte / P15090* / fatty acid binding protein 4*ENSMUSG0000006251550
Fabp12 / Q9DAK4 / Fatty acid-binding protein 12 / A6NFH5*ENSMUSG0000002753050
Pmp2 / P24526 / peripheral myelin protein 2 / P02689*ENSMUSG0000005246850
Fabp3 / P11404 / Fatty acid-binding protein, heart / P05413* / fatty acid binding protein 3*ENSMUSG0000002877344
Fabp9 / O08716 / Fatty acid-binding protein 9 / Q0Z7S8*ENSMUSG0000002752844
Fabp7 / P51880 / Fatty acid-binding protein, brain / O15540* / fatty acid binding protein 7*ENSMUSG0000001987439
Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*ENSMUSG0000003229133
Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*ENSMUSG0000000488533
Rbp2 / Q08652 / retinol binding protein 2, cellular / P50120* / retinol binding protein 2*ENSMUSG0000003245431
Rbp1 / Q00915 / retinol binding protein 1, cellular / P09455* / retinol binding protein 1*ENSMUSG0000004640230
Rbp7 / Q9EPC5 / retinol binding protein 7, cellular / Q96R05* / retinol binding protein 7*ENSMUSG0000002899626
Gm37389 / FABP9* / Q0Z7S8* / fatty acid binding protein 9*ENSMUSG0000010312424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IGI
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Triglyceride catabolism
Signaling by Retinoic Acid
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp5tm1Hota Lepob

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002250 Ppard / P35396 / Peroxisome proliferator-activated receptor delta / Q03181*  / complex / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction






 

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