ENSMUSG00000028773


Mus musculus

Features
Gene ID: ENSMUSG00000028773
  
Biological name :Fabp3
  
Synonyms : Fabp3 / Fatty acid-binding protein, heart / P11404
  
Possible biological names infered from orthology : fatty acid binding protein 3 / P05413
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 130308595
Gene end: 130315463
  
Corresponding Affymetrix probe sets: 10371502 (MoGene1.0st)   10508614 (MoGene1.0st)   1416023_at (Mouse Genome 430 2.0 Array)   1444844_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070709
NCBI entrez gene - 14077     See in Manteia.
MGI - MGI:95476
RefSeq - NM_010174
RefSeq Peptide - NP_034304
swissprot - P11404
swissprot - Q5EBJ0
Ensembl - ENSMUSG00000028773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fabp3ENSDARG00000023290Danio rerio
 FABP3ENSGALG00000037050Gallus gallus
 FABP3ENSG00000121769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fabp7 / P51880 / Fatty acid-binding protein, brain / O15540* / fatty acid binding protein 7*ENSMUSG0000001987465
Fabp4 / P04117 / Fatty acid-binding protein, adipocyte / P15090* / fatty acid binding protein 4*ENSMUSG0000006251563
Pmp2 / P24526 / peripheral myelin protein 2 / P02689*ENSMUSG0000005246858
Fabp9 / O08716 / Fatty acid-binding protein 9 / Q0Z7S8*ENSMUSG0000002752850
Fabp12 / Q9DAK4 / Fatty acid-binding protein 12 / A6NFH5*ENSMUSG0000002753050
Fabp5 / Q05816 / Fatty acid-binding protein, epidermal / Q01469* / fatty acid binding protein 5*ENSMUSG0000002753345
Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*ENSMUSG0000000488544
Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*ENSMUSG0000003229143
Rbp2 / Q08652 / retinol binding protein 2, cellular / P50120* / retinol binding protein 2*ENSMUSG0000003245440
Rbp7 / Q9EPC5 / retinol binding protein 7, cellular / Q96R05* / retinol binding protein 7*ENSMUSG0000002899638
Rbp1 / Q00915 / retinol binding protein 1, cellular / P09455* / retinol binding protein 1*ENSMUSG0000004640236
Gm37389 / FABP9* / Q0Z7S8* / fatty acid binding protein 9*ENSMUSG0000010312432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0015909 long-chain fatty acid transport IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0044539 long-chain fatty acid import IMP
 biological_processGO:0046320 regulation of fatty acid oxidation IMP
 biological_processGO:0055091 phospholipid homeostasis IMP
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071073 positive regulation of phospholipid biosynthetic process IC
 biological_processGO:2001245 regulation of phosphatidylcholine biosynthetic process IGI
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016528 sarcoplasm IEA
 molecular_functionGO:0005324 long-chain fatty acid transporter activity IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0036041 long-chain fatty acid binding IEA
 molecular_functionGO:0050543 icosatetraenoic acid binding IEA
 molecular_functionGO:0070538 oleic acid binding IEA


Pathways (from Reactome)
Pathway description
Triglyceride catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0010358 abnormal free fatty acids level "any anomaly in the concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
Show

Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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