ENSMUSG00000046402


Mus musculus

Features
Gene ID: ENSMUSG00000046402
  
Biological name :Rbp1
  
Synonyms : Q00915 / Rbp1 / retinol binding protein 1, cellular
  
Possible biological names infered from orthology : P09455 / retinol binding protein 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 98422961
Gene end: 98446575
  
Corresponding Affymetrix probe sets: 10588037 (MoGene1.0st)   1448754_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059749
NCBI entrez gene - 19659     See in Manteia.
MGI - MGI:97876
RefSeq - NM_011254
RefSeq Peptide - NP_035384
swissprot - Q00915
swissprot - Q58EU7
Ensembl - ENSMUSG00000046402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbp1ENSDARG00000018077Danio rerio
 RBP1 (1 of many)ENSDARG00000038742Danio rerio
 RBP1ENSGALG00000037875Gallus gallus
 RBP1ENSG00000114115Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbp7 / Q9EPC5 / retinol binding protein 7, cellular / Q96R05* / retinol binding protein 7*ENSMUSG0000002899656
Rbp2 / Q08652 / retinol binding protein 2, cellular / P50120* / retinol binding protein 2*ENSMUSG0000003245456
Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*ENSMUSG0000003229142
Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*ENSMUSG0000000488541
Fabp7 / P51880 / Fatty acid-binding protein, brain / O15540* / fatty acid binding protein 7*ENSMUSG0000001987436
Fabp3 / P11404 / Fatty acid-binding protein, heart / P05413* / fatty acid binding protein 3*ENSMUSG0000002877336
Fabp4 / P04117 / Fatty acid-binding protein, adipocyte / P15090* / fatty acid binding protein 4*ENSMUSG0000006251536
Pmp2 / P24526 / peripheral myelin protein 2 / P02689*ENSMUSG0000005246835
Fabp12 / Q9DAK4 / Fatty acid-binding protein 12 / A6NFH5*ENSMUSG0000002753035
Fabp9 / O08716 / Fatty acid-binding protein 9 / Q0Z7S8*ENSMUSG0000002752833
Fabp5 / Q05816 / Fatty acid-binding protein, epidermal / Q01469* / fatty acid binding protein 5*ENSMUSG0000002753330
Gm37389 / FABP9* / Q0Z7S8* / fatty acid binding protein 9*ENSMUSG0000010312427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein
 IPR031264  Retinol-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002138 retinoic acid biosynthetic process IEA
 biological_processGO:0006776 vitamin A metabolic process ISO
 biological_processGO:0030852 regulation of granulocyte differentiation IMP
 biological_processGO:0033189 response to vitamin A IMP
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042573 retinoic acid metabolic process IMP
 biological_processGO:0055088 lipid homeostasis ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0005501 retinoid binding TAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016918 retinal binding IEA
 molecular_functionGO:0019841 retinol binding IEA
 molecular_functionGO:1904768 all-trans-retinol binding ISO


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0005444 abnormal retinol metabolism "altered ability to metabolize this organic compound that plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:55555]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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