ENSMUSG00000062515


Mus musculus

Features
Gene ID: ENSMUSG00000062515
  
Biological name :Fabp4
  
Synonyms : Fabp4 / Fatty acid-binding protein, adipocyte / P04117
  
Possible biological names infered from orthology : fatty acid binding protein 4 / P15090
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 10204088
Gene end: 10208576
  
Corresponding Affymetrix probe sets: 10497265 (MoGene1.0st)   1417023_a_at (Mouse Genome 430 2.0 Array)   1424155_at (Mouse Genome 430 2.0 Array)   1425809_at (Mouse Genome 430 2.0 Array)   1451263_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029041
NCBI entrez gene - 11770     See in Manteia.
MGI - MGI:88038
RefSeq - NM_024406
RefSeq Peptide - NP_077717
swissprot - P04117
swissprot - Q542H7
Ensembl - ENSMUSG00000062515
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01088982.1ENSDARG00000109259Danio rerio
 fabp11aENSDARG00000017299Danio rerio
 fabp11bENSDARG00000002311Danio rerio
 FABP4ENSGALG00000030025Gallus gallus
 FABP4ENSG00000170323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pmp2 / P24526 / peripheral myelin protein 2 / P02689*ENSMUSG0000005246865
Fabp3 / P11404 / Fatty acid-binding protein, heart / P05413* / fatty acid binding protein 3*ENSMUSG0000002877364
Fabp9 / O08716 / Fatty acid-binding protein 9 / Q0Z7S8*ENSMUSG0000002752859
Fabp12 / Q9DAK4 / Fatty acid-binding protein 12 / A6NFH5*ENSMUSG0000002753055
Fabp7 / P51880 / Fatty acid-binding protein, brain / O15540* / fatty acid binding protein 7*ENSMUSG0000001987453
Fabp5 / Q05816 / Fatty acid-binding protein, epidermal / Q01469* / fatty acid binding protein 5*ENSMUSG0000002753352
Rbp2 / Q08652 / retinol binding protein 2, cellular / P50120* / retinol binding protein 2*ENSMUSG0000003245439
Rbp7 / Q9EPC5 / retinol binding protein 7, cellular / Q96R05* / retinol binding protein 7*ENSMUSG0000002899639
Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*ENSMUSG0000003229138
Rbp1 / Q00915 / retinol binding protein 1, cellular / P09455* / retinol binding protein 1*ENSMUSG0000004640237
Gm37389 / FABP9* / Q0Z7S8* / fatty acid binding protein 9*ENSMUSG0000010312436
Crabp2 / P22935 / Cellular retinoic acid-binding protein 2 / P29373*ENSMUSG0000000488536


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein
 IPR033073  Fatty acid-binding protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0050872 white fat cell differentiation IDA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Triglyceride catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Lepob

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
Show

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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