ENSG00000112033


Homo sapiens

Features
Gene ID: ENSG00000112033
  
Biological name :PPARD
  
Synonyms : peroxisome proliferator activated receptor delta / PPARD / Q03181
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.31
Gene start: 35342558
Gene end: 35428191
  
Corresponding Affymetrix probe sets: 208044_s_at (Human Genome U133 Plus 2.0 Array)   210636_at (Human Genome U133 Plus 2.0 Array)   37152_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310928
Ensembl peptide - ENSP00000353916
Ensembl peptide - ENSP00000413314
Ensembl peptide - ENSP00000414372
Ensembl peptide - ENSP00000337063
NCBI entrez gene - 5467     See in Manteia.
OMIM - 600409
RefSeq - XM_017010975
RefSeq - XM_006715123
RefSeq - XM_011514707
RefSeq - XM_011514709
RefSeq - XM_011514710
RefSeq - XM_017010971
RefSeq - XM_017010972
RefSeq - XM_017010973
RefSeq - XM_017010974
RefSeq - NM_001171818
RefSeq - NM_001171819
RefSeq - NM_001171820
RefSeq - NM_006238
RefSeq - NM_177435
RefSeq - XM_005249193
RefSeq - XM_006715120
RefSeq Peptide - NP_006229
RefSeq Peptide - NP_001165289
RefSeq Peptide - NP_001165290
RefSeq Peptide - NP_803184
RefSeq Peptide - NP_001165291
swissprot - Q03181
swissprot - F1D8S7
swissprot - A0A024RCW6
Ensembl - ENSG00000112033
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppardaENSDARG00000044525Danio rerio
 ppardbENSDARG00000009473Danio rerio
 PPARDENSGALG00000002588Gallus gallus
 PpardENSMUSG00000002250Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695164
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217058
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473830
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636828
RORC / P51449 / RAR related orphan receptor CENSG0000014336526
RORA / P35398 / RAR related orphan receptor AENSG0000006966726
RORB / Q92753 / RAR related orphan receptor BENSG0000019896324
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683320
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693119
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003074  Peroxisome proliferator-activated receptor
 IPR003075  Peroxisome proliferator-activated receptor, beta
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006006 glucose metabolic process NAS
 biological_processGO:0006029 proteoglycan metabolic process IEA
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006635 fatty acid beta-oxidation TAS
 biological_processGO:0006776 vitamin A metabolic process IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007566 embryo implantation TAS
 biological_processGO:0008203 cholesterol metabolic process TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008366 axon ensheathment ISS
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009062 fatty acid catabolic process TAS
 biological_processGO:0009299 mRNA transcription IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0015908 fatty acid transport ISS
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043415 positive regulation of skeletal muscle tissue regeneration IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045598 regulation of fat cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation NAS
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045684 positive regulation of epidermis development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046697 decidualization TAS
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0051546 keratinocyte migration IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0097190 apoptotic signaling pathway IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISS
 biological_processGO:1904659 glucose transmembrane transport NAS
 biological_processGO:2000288 positive regulation of myoblast proliferation IEA
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0070539 linoleic acid binding IDA


Pathways (from Reactome)
Pathway description
Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164687 FABP5 / Q01469 / fatty acid binding protein 5  / reaction / complex
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex






 

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