ENSG00000186951


Homo sapiens

Features
Gene ID: ENSG00000186951
  
Biological name :PPARA
  
Synonyms : peroxisome proliferator activated receptor alpha / PPARA / Q07869
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.31
Gene start: 46150521
Gene end: 46243756
  
Corresponding Affymetrix probe sets: 1558631_at (Human Genome U133 Plus 2.0 Array)   1560981_a_at (Human Genome U133 Plus 2.0 Array)   206870_at (Human Genome U133 Plus 2.0 Array)   210771_at (Human Genome U133 Plus 2.0 Array)   223437_at (Human Genome U133 Plus 2.0 Array)   223438_s_at (Human Genome U133 Plus 2.0 Array)   226978_at (Human Genome U133 Plus 2.0 Array)   237142_at (Human Genome U133 Plus 2.0 Array)   244689_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397291
Ensembl peptide - ENSP00000385523
Ensembl peptide - ENSP00000411677
Ensembl peptide - ENSP00000414752
Ensembl peptide - ENSP00000262735
Ensembl peptide - ENSP00000385246
NCBI entrez gene - 5465     See in Manteia.
OMIM - 170998
RefSeq - XM_017028840
RefSeq - XM_011530240
RefSeq - XM_011530241
RefSeq - XM_011530242
RefSeq - XM_011530243
RefSeq - XM_011530244
RefSeq - XM_011530245
RefSeq - XM_017028839
RefSeq - NM_001001928
RefSeq - NM_005036
RefSeq - XM_005261655
RefSeq - XM_005261656
RefSeq - XM_006724269
RefSeq - XM_006724270
RefSeq - XM_011530239
RefSeq Peptide - NP_005027
RefSeq Peptide - NP_001001928
swissprot - Q86SF0
swissprot - B0QYX2
swissprot - Q07869
swissprot - B0QYX1
swissprot - F1D8S4
Ensembl - ENSG00000186951
  
Related genetic diseases (OMIM): 170998 - {Hyperapobetalipoproteinemia, susceptibility to}

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pparaaENSDARG00000031777Danio rerio
 pparabENSDARG00000054323Danio rerio
 PPARAENSGALG00000041470Gallus gallus
 PparaENSMUSG00000022383Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203360
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217056
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473829
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636828
RORA / P35398 / RAR related orphan receptor AENSG0000006966725
RORC / P51449 / RAR related orphan receptor CENSG0000014336523
RORB / Q92753 / RAR related orphan receptor BENSG0000019896322
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683320
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820018
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003074  Peroxisome proliferator-activated receptor
 IPR003076  Peroxisome proliferator-activated receptor alpha
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006631 fatty acid metabolic process TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IDA
 biological_processGO:0010871 negative regulation of receptor biosynthetic process IDA
 biological_processGO:0010887 negative regulation of cholesterol storage IDA
 biological_processGO:0010891 negative regulation of sequestering of triglyceride IDA
 biological_processGO:0015908 fatty acid transport TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019217 regulation of fatty acid metabolic process IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation TAS
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032099 negative regulation of appetite ISS
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045820 negative regulation of glycolytic process IC
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046321 positive regulation of fatty acid oxidation ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0070166 enamel mineralization IEA
 biological_processGO:0072363 regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter IDA
 biological_processGO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter IDA
 biological_processGO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter IDA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1903038 negative regulation of leukocyte cell-cell adhesion IDA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0003707 steroid hormone receptor activity IDA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051525 NFAT protein binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000163586 FABP1 / P07148 / fatty acid binding protein 1  / reaction
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex / reaction






 

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