ENSG00000198963


Homo sapiens

Features
Gene ID: ENSG00000198963
  
Biological name :RORB
  
Synonyms : Q92753 / RAR related orphan receptor B / RORB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.13
Gene start: 74497365
Gene end: 74693177
  
Corresponding Affymetrix probe sets: 206443_at (Human Genome U133 Plus 2.0 Array)   231040_at (Human Genome U133 Plus 2.0 Array)   242385_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366093
Ensembl peptide - ENSP00000379507
NCBI entrez gene - 6096     See in Manteia.
OMIM - 601972
RefSeq - NM_006914
RefSeq Peptide - NP_008845
swissprot - A0A1L4FMK7
swissprot - Q58EY0
swissprot - Q92753
Ensembl - ENSG00000198963
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rorbENSDARG00000033498Danio rerio
 RORBENSGALG00000015150Gallus gallus
 RorbENSMUSG00000036192Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RORA / P35398 / RAR related orphan receptor AENSG0000006966764
RORC / P51449 / RAR related orphan receptor CENSG0000014336553
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473830
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636829
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217023
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695123
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203323
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683321
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693120
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003079  Nuclear receptor ROR
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0035881 amacrine cell differentiation ISS
 biological_processGO:0042462 eye photoreceptor cell development ISS
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046548 retinal rod cell development ISS
 biological_processGO:0046549 retinal cone cell development ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060041 retina development in camera-type eye ISS
 biological_processGO:0071300 cellular response to retinoic acid ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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