ENSG00000174738


Homo sapiens

Features
Gene ID: ENSG00000174738
  
Biological name :NR1D2
  
Synonyms : NR1D2 / nuclear receptor subfamily 1 group D member 2 / Q14995
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p24.2
Gene start: 23945260
Gene end: 23980618
  
Corresponding Affymetrix probe sets: 209750_at (Human Genome U133 Plus 2.0 Array)   225768_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310006
Ensembl peptide - ENSP00000373283
NCBI entrez gene - 9975     See in Manteia.
OMIM - 602304
RefSeq - XM_006713451
RefSeq - NM_001145425
RefSeq - NM_005126
RefSeq Peptide - NP_001138897
RefSeq Peptide - NP_005117
swissprot - Q14995
swissprot - Q6NSM0
swissprot - F1D8P2
Ensembl - ENSG00000174738
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1d2bENSDARG00000009594Danio rerio
 NR1D2ENSGALG00000011291Gallus gallus
 Nr1d2ENSMUSG00000021775Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636854
RORA / P35398 / RAR related orphan receptor AENSG0000006966725
RORC / P51449 / RAR related orphan receptor CENSG0000014336525
RORB / Q92753 / RAR related orphan receptor BENSG0000019896324
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695124
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203323
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683322
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217022
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693118
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0019216 regulation of lipid metabolic process ISS
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0055088 lipid homeostasis ISS
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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