ENSG00000069667


Homo sapiens

Features
Gene ID: ENSG00000069667
  
Biological name :RORA
  
Synonyms : P35398 / RAR related orphan receptor A / RORA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.2
Gene start: 60488284
Gene end: 61229319
  
Corresponding Affymetrix probe sets: 210426_x_at (Human Genome U133 Plus 2.0 Array)   210479_s_at (Human Genome U133 Plus 2.0 Array)   226682_at (Human Genome U133 Plus 2.0 Array)   235567_at (Human Genome U133 Plus 2.0 Array)   236266_at (Human Genome U133 Plus 2.0 Array)   239550_at (Human Genome U133 Plus 2.0 Array)   240951_at (Human Genome U133 Plus 2.0 Array)   241760_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402971
Ensembl peptide - ENSP00000335087
Ensembl peptide - ENSP00000449482
Ensembl peptide - ENSP00000484955
Ensembl peptide - ENSP00000453322
Ensembl peptide - ENSP00000261523
Ensembl peptide - ENSP00000309753
NCBI entrez gene - 6095     See in Manteia.
OMIM - 600825
RefSeq - XM_017022467
RefSeq - NM_134260
RefSeq - NM_134261
RefSeq - NM_134262
RefSeq - XM_005254584
RefSeq - XM_011521874
RefSeq - XM_011521875
RefSeq - XM_011521877
RefSeq - XM_011521878
RefSeq - XM_011521879
RefSeq - XM_017022466
RefSeq - NM_002943
RefSeq Peptide - NP_599022
RefSeq Peptide - NP_599023
RefSeq Peptide - NP_599024
RefSeq Peptide - NP_002934
swissprot - A0A087X2G0
swissprot - A0A0C4DG53
swissprot - P35398
swissprot - A0A0C4DFP5
swissprot - H0YII6
swissprot - H0YLS5
Ensembl - ENSG00000069667
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 roraaENSDARG00000031768Danio rerio
 RORAENSGALG00000003759Gallus gallus
 RoraENSMUSG00000032238Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RORB / Q92753 / RAR related orphan receptor BENSG0000019896353
RORC / P51449 / RAR related orphan receptor CENSG0000014336544
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473826
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636824
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203321
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695121
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217020
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683318
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693116
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003079  Nuclear receptor ROR
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008589 regulation of smoothened signaling pathway IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0019218 regulation of steroid metabolic process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IEA
 biological_processGO:0021930 cerebellar granule cell precursor proliferation IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0036315 cellular response to sterol IMP
 biological_processGO:0042692 muscle cell differentiation IMP
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042753 positive regulation of circadian rhythm IEA
 biological_processGO:0043030 regulation of macrophage activation IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046068 cGMP metabolic process IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0060850 regulation of transcription involved in cell fate commitment IEA
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0072539 T-helper 17 cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001222 transcription corepressor binding IPI
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008142 oxysterol binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
PPARA activates gene expression
Nuclear Receptor transcription pathway
Circadian Clock
SUMOylation of intracellular receptors
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000180530 NRIP1 / P48552 / nuclear receptor interacting protein 1  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction






 

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