ENSG00000116833


Homo sapiens

Features
Gene ID: ENSG00000116833
  
Biological name :NR5A2
  
Synonyms : NR5A2 / nuclear receptor subfamily 5 group A member 2 / O00482
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 200027602
Gene end: 200177424
  
Corresponding Affymetrix probe sets: 1560469_at (Human Genome U133 Plus 2.0 Array)   208337_s_at (Human Genome U133 Plus 2.0 Array)   208343_s_at (Human Genome U133 Plus 2.0 Array)   210174_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436776
Ensembl peptide - ENSP00000414888
Ensembl peptide - ENSP00000439116
Ensembl peptide - ENSP00000236914
Ensembl peptide - ENSP00000356326
Ensembl peptide - ENSP00000356331
NCBI entrez gene - 2494     See in Manteia.
OMIM - 604453
RefSeq - XM_017000904
RefSeq - NM_001276464
RefSeq - NM_003822
RefSeq - NM_205860
RefSeq - XM_005245062
RefSeq - XM_011509380
RefSeq - XM_011509381
RefSeq - XM_011509382
RefSeq - XM_011509384
RefSeq Peptide - NP_995582
RefSeq Peptide - NP_001263393
RefSeq Peptide - NP_003813
swissprot - F1D8R9
swissprot - E9PQH2
swissprot - O00482
swissprot - H0Y328
swissprot - H0Y7S7
Ensembl - ENSG00000116833
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr5a2ENSDARG00000100940Danio rerio
 NR5A2ENSGALG00000002182Gallus gallus
 Nr5a2ENSMUSG00000026398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693153
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473824
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636822
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820020
RORA / P35398 / RAR related orphan receptor AENSG0000006966719
RORC / P51449 / RAR related orphan receptor CENSG0000014336519
RORB / Q92753 / RAR related orphan receptor BENSG0000019896318
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217018
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203317
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016355  Nuclear hormone receptor family 5
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0008206 bile acid metabolic process IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0009792 embryo development ending in birth or egg hatching TAS
 biological_processGO:0009888 tissue development IBA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042592 homeostatic process NAS
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045070 positive regulation of viral genome replication IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0061113 pancreas morphogenesis IEA
 biological_processGO:0097720 calcineurin-mediated signaling IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000171940 O75362 / ZNF217 / zinc finger protein 217  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex
 ENSG00000124151 NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr