ENSG00000126368


Homo sapiens

Features
Gene ID: ENSG00000126368
  
Biological name :NR1D1
  
Synonyms : NR1D1 / nuclear receptor subfamily 1 group D member 1 / P20393
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.1
Gene start: 40092787
Gene end: 40100725
  
Corresponding Affymetrix probe sets: 204760_s_at (Human Genome U133 Plus 2.0 Array)   31637_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246672
NCBI entrez gene - 9572     See in Manteia.
OMIM - 602408
RefSeq - NM_021724
RefSeq Peptide - NP_068370
swissprot - F1D8S3
swissprot - P20393
Ensembl - ENSG00000126368
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr1d1ENSDARG00000033160Danio rerio
 Nr1d1ENSMUSG00000020889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473850
RORC / P51449 / RAR related orphan receptor CENSG0000014336523
RORA / P35398 / RAR related orphan receptor AENSG0000006966722
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695121
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217021
RORB / Q92753 / RAR related orphan receptor BENSG0000019896321
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203320
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683319
NR6A1 / Q15406 / nuclear receptor subfamily 6 group A member 1ENSG0000014820016
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0005978 glycogen biosynthetic process ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0010498 proteasomal protein catabolic process ISS
 biological_processGO:0010871 negative regulation of receptor biosynthetic process IMP
 biological_processGO:0019216 regulation of lipid metabolic process ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway IMP
 biological_processGO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0044321 response to leptin ISS
 biological_processGO:0045598 regulation of fat cell differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060086 circadian temperature homeostasis ISS
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation ISS
 biological_processGO:0070859 positive regulation of bile acid biosynthetic process ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001222 transcription corepressor binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / complex






 

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