ENSG00000141027


Homo sapiens

Features
Gene ID: ENSG00000141027
  
Biological name :NCOR1
  
Synonyms : NCOR1 / nuclear receptor corepressor 1 / O75376
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 16029157
Gene end: 16218185
  
Corresponding Affymetrix probe sets: 200854_at (Human Genome U133 Plus 2.0 Array)   200855_at (Human Genome U133 Plus 2.0 Array)   200856_x_at (Human Genome U133 Plus 2.0 Array)   200857_s_at (Human Genome U133 Plus 2.0 Array)   234313_at (Human Genome U133 Plus 2.0 Array)   240314_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410784
Ensembl peptide - ENSP00000407998
Ensembl peptide - ENSP00000461959
Ensembl peptide - ENSP00000474008
Ensembl peptide - ENSP00000463169
Ensembl peptide - ENSP00000462794
Ensembl peptide - ENSP00000462308
Ensembl peptide - ENSP00000462281
Ensembl peptide - ENSP00000268712
Ensembl peptide - ENSP00000379189
Ensembl peptide - ENSP00000379190
Ensembl peptide - ENSP00000379192
Ensembl peptide - ENSP00000379198
Ensembl peptide - ENSP00000387727
Ensembl peptide - ENSP00000389839
NCBI entrez gene - 9611     See in Manteia.
OMIM - 600849
RefSeq - XM_017025420
RefSeq - XM_017025403
RefSeq - XM_017025404
RefSeq - XM_017025405
RefSeq - XM_017025406
RefSeq - XM_017025407
RefSeq - XM_017025408
RefSeq - XM_017025409
RefSeq - XM_017025410
RefSeq - XM_017025411
RefSeq - XM_017025412
RefSeq - XM_017025413
RefSeq - XM_017025414
RefSeq - XM_017025415
RefSeq - XM_017025416
RefSeq - XM_017025417
RefSeq - XM_017025418
RefSeq - XM_017025419
RefSeq - NM_001190438
RefSeq - NM_001190440
RefSeq - NM_006311
RefSeq - XM_005256866
RefSeq - XM_005256868
RefSeq - XM_005256871
RefSeq - XM_005256872
RefSeq - XM_005256873
RefSeq - XM_005256874
RefSeq - XM_005256875
RefSeq - XM_006721601
RefSeq - XM_006721602
RefSeq - XM_006721603
RefSeq - XM_006721604
RefSeq - XM_011524083
RefSeq - XM_011524084
RefSeq - XM_011524085
RefSeq - XM_011524086
RefSeq - XM_017025396
RefSeq - XM_017025397
RefSeq - XM_017025398
RefSeq - XM_017025399
RefSeq - XM_017025400
RefSeq - XM_017025401
RefSeq - XM_017025402
RefSeq Peptide - NP_001177367
RefSeq Peptide - NP_001177369
RefSeq Peptide - NP_006302
swissprot - C9JAP0
swissprot - A0A088AWL3
swissprot - H0Y459
swissprot - J3KRE4
swissprot - J3KS29
swissprot - E7EW50
swissprot - J3KT44
swissprot - J3QKP0
swissprot - O75376
swissprot - S4R380
swissprot - A0A024RD47
swissprot - J3KS51
swissprot - E7EVU5
swissprot - E7EVK1
Ensembl - ENSG00000141027
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncor1ENSDARG00000035285Danio rerio
 NCOR1ENSGALG00000004477Gallus gallus
 Ncor1ENSMUSG00000018501Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCOR2 / Q9Y618 / nuclear receptor corepressor 2ENSG0000019649843
RCOR3 / Q9P2K3 / REST corepressor 3ENSG000001176256
RCOR2 / Q8IZ40 / REST corepressor 2ENSG000001677715
RCOR1 / Q9UKL0 / REST corepressor 1ENSG000000899024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR031557  N-CoR, GPS2-interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0046329 negative regulation of JNK cascade IDA
 biological_processGO:0051225 spindle assembly IMP
 biological_processGO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:2000191 regulation of fatty acid transport IC
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016580 Sin3 complex IDA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016922 nuclear receptor binding IBA
 molecular_functionGO:0035257 nuclear hormone receptor binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046966 thyroid hormone receptor binding IBA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126368 NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1  / complex
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / complex / reaction
 ENSG00000132170 PPARG / P37231 / peroxisome proliferator activated receptor gamma  / reaction / complex
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / reaction / complex
 ENSG00000157933 SKI / P12755 / SKI proto-oncogene  / complex / reaction
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / complex
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex / reaction
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / reaction / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex
 ENSG00000136603 SKIL / P12757 / SKI like proto-oncogene  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction / complex
 ENSG00000204231 RXRB / P28702 / retinoid X receptor beta  / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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