ENSG00000196498


Homo sapiens

Features
Gene ID: ENSG00000196498
  
Biological name :NCOR2
  
Synonyms : NCOR2 / nuclear receptor corepressor 2 / Q9Y618
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 124324415
Gene end: 124567589
  
Corresponding Affymetrix probe sets: 207760_s_at (Human Genome U133 Plus 2.0 Array)   208888_s_at (Human Genome U133 Plus 2.0 Array)   208889_s_at (Human Genome U133 Plus 2.0 Array)   215205_x_at (Human Genome U133 Plus 2.0 Array)   236025_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398963
Ensembl peptide - ENSP00000400281
Ensembl peptide - ENSP00000443689
Ensembl peptide - ENSP00000408247
Ensembl peptide - ENSP00000407357
Ensembl peptide - ENSP00000405367
Ensembl peptide - ENSP00000403034
Ensembl peptide - ENSP00000402808
Ensembl peptide - ENSP00000400687
Ensembl peptide - ENSP00000348551
Ensembl peptide - ENSP00000384018
Ensembl peptide - ENSP00000384202
Ensembl peptide - ENSP00000385618
Ensembl peptide - ENSP00000391389
Ensembl peptide - ENSP00000396044
NCBI entrez gene - 9612     See in Manteia.
OMIM - 600848
RefSeq - NM_001206654
RefSeq - NM_006312
RefSeq - NM_001077261
RefSeq Peptide - NP_001070729
RefSeq Peptide - NP_001193583
RefSeq Peptide - NP_006303
swissprot - C9J0Q5
swissprot - H0YGK8
swissprot - H7BZU2
swissprot - H7C0P3
swissprot - H7C184
swissprot - H7C1J7
swissprot - H7C1Y3
swissprot - H7C2R5
swissprot - C9JQE8
swissprot - Q9Y618
swissprot - C9JNV9
swissprot - C9JFD3
swissprot - C9JE98
swissprot - C9J7T7
swissprot - C9J330
Ensembl - ENSG00000196498
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncor2ENSDARG00000000966Danio rerio
 NCOR2ENSGALG00000003120Gallus gallus
 Ncor2ENSMUSG00000029478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCOR1 / O75376 / nuclear receptor corepressor 1ENSG0000014102742
RCOR3 / Q9P2K3 / REST corepressor 3ENSG000001176255
RCOR2 / Q8IZ40 / REST corepressor 2ENSG000001677715
RCOR1 / Q9UKL0 / REST corepressor 1ENSG000000899024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR031557  N-CoR, GPS2-interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IMP
 cellular_componentGO:0000118 histone deacetylase complex IBA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0016922 nuclear receptor binding IBA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0042974 retinoic acid receptor binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / reaction / complex
 ENSG00000132170 PPARG / P37231 / peroxisome proliferator activated receptor gamma  / complex / reaction
 ENSG00000171720 HDAC3 / O15379 / histone deacetylase 3  / reaction / complex
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / reaction / complex
 ENSG00000157933 SKI / P12755 / SKI proto-oncogene  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000101849 TBL1X / O60907 / transducin beta like 1 X-linked  / complex
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000204231 RXRB / P28702 / retinoid X receptor beta  / complex
 ENSG00000136603 SKIL / P12757 / SKI like proto-oncogene  / reaction / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction / complex
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex
 ENSG00000177565 Q9BZK7 / TBL1XR1 / transducin beta like 1 X-linked receptor 1  / complex
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / complex
 ENSG00000132522 GPS2 / Q13227 / G protein pathway suppressor 2  / complex






 

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