ENSDARG00000000966


Danio rerio

Features
Gene ID: ENSDARG00000000966
  
Biological name :ncor2
  
Synonyms : ncor2 / nuclear receptor corepressor 2
  
Possible biological names infered from orthology : Q9WU42 / Q9Y618
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 43379436
Gene end: 43574935
  
Corresponding Affymetrix probe sets: Dr.13912.1.S1_at (Zebrafish Array)   Dr.16777.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000001475
Ensembl peptide - ENSDARP00000051138
Ensembl peptide - ENSDARP00000121486
NCBI entrez gene - 561503     See in Manteia.
RefSeq - NM_001007032
RefSeq Peptide - NP_001007033
swissprot - F1R8E1
swissprot - E7FF48
swissprot - F1R8Z8
ZFIN ID - ZDB-GENE-030616-81
Ensembl - ENSDARG00000000966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCOR2ENSGALG00000003120Gallus gallus
 NCOR2ENSG00000196498Homo sapiens
 Ncor2ENSMUSG00000029478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ncor1 / nuclear receptor corepressor 1 / O75376* / nuclear receptor co-repressor 1*ENSDARG0000003528537
rcor3 / REST corepressor 3 / Q6PGA0* / Q9P2K3*ENSDARG000000045025
rcor1 / REST corepressor 1 / Q8CFE3* / Q9UKL0*ENSDARG000000314344
rcor2 / Q6P116 / REST corepressor 2 / Q8C796* / Q8IZ40*ENSDARG000000082784


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR031557  N-CoR, GPS2-interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030223 neutrophil differentiation IMP
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 cellular_componentGO:0000118 histone deacetylase complex IBA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0016922 nuclear receptor binding IBA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000005 artery artery increased size , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta increased size , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009141 macrophage macrophage decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000022904 skilb / SKI-like proto-oncogene b / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000023933 skila / SKI-like proto-oncogene a / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000008034 skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*  / complex / reaction






 

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