ENSDARG00000023933


Danio rerio

Features
Gene ID: ENSDARG00000023933
  
Biological name :skila
  
Synonyms : skila / SKI-like proto-oncogene a
  
Possible biological names infered from orthology : P12757 / Q60665 / SKIL / SKI-like / SKI like proto-oncogene
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 37307326
Gene end: 37353098
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000056521
Ensembl peptide - ENSDARP00000113304
Ensembl peptide - ENSDARP00000116499
Ensembl peptide - ENSDARP00000154019
swissprot - F1QXU7
swissprot - F1R1T6
swissprot - F1RB91
ZFIN ID - ZDB-GENE-070912-548
Ensembl - ENSDARG00000023933
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SKILENSGALG00000009356Gallus gallus
 SKILENSG00000136603Homo sapiens
 SkilENSMUSG00000027660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
skilb / SKI-like proto-oncogene b / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSDARG0000002290448
skia / v-ski avian sarcoma viral oncogene homolog a / SKI* / P12755* / SKI proto-oncogene*ENSDARG0000004215138
skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*ENSDARG0000000803436
skor1a / SKI family transcriptional corepressor 1a / SKOR1* / P84550* / Q8BX46* / SKI family transcriptional corepressor 1*ENSDARG0000006903019
Q1LXZ9 / skor1b / SKI family transcriptional corepressor 1b / SKOR1* / Q8BX46* / P84550* / SKI family transcriptional corepressor 1*ENSDARG0000006244815
zgc:153395 / SKOR2* / Q2VWA4* / SKI family transcriptional corepressor 2*ENSDARG0000006361412


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028373  Ski-related oncogene Sno


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0045596 negative regulation of cell differentiation IBA
 biological_processGO:0048666 neuron development IBA
 molecular_functionGO:0046332 SMAD binding IBA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000000966 ncor2 / nuclear receptor corepressor 2 / Q9WU42* / Q9Y618*  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / reaction / complex






 

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