ENSDARG00000042151


Danio rerio

Features
Gene ID: ENSDARG00000042151
  
Biological name :skia
  
Synonyms : skia / v-ski avian sarcoma viral oncogene homolog a
  
Possible biological names infered from orthology : P12755 / SKI / SKI proto-oncogene
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 17395929
Gene end: 17516448
  
Corresponding Affymetrix probe sets: Dr.8082.1.S1_at (Zebrafish Array)   NM_130935_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000091440
NCBI entrez gene - 30101     See in Manteia.
RefSeq - NM_130935
RefSeq Peptide - NP_571010
swissprot - B0S7D7
ZFIN ID - ZDB-GENE-990715-9
Ensembl - ENSDARG00000042151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SKIENSGALG00000001229Gallus gallus
 SKIENSG00000157933Homo sapiens
 SkiENSMUSG00000029050Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*ENSDARG0000000803461
skila / SKI-like proto-oncogene a / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSDARG0000002393332
skilb / SKI-like proto-oncogene b / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSDARG0000002290430
skor1a / SKI family transcriptional corepressor 1a / SKOR1* / P84550* / Q8BX46* / SKI family transcriptional corepressor 1*ENSDARG0000006903020
Q1LXZ9 / skor1b / SKI family transcriptional corepressor 1b / SKOR1* / Q8BX46* / P84550* / SKI family transcriptional corepressor 1*ENSDARG0000006244818
zgc:153395 / SKOR2* / Q2VWA4* / SKI family transcriptional corepressor 2*ENSDARG0000006361411


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028760  Ski oncogene


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0045596 negative regulation of cell differentiation IBA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0061337 cardiac conduction IGI
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0046332 SMAD binding IBA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart decreased functionality , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus amorphous , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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