ENSDARG00000008034


Danio rerio

Features
Gene ID: ENSDARG00000008034
  
Biological name :skib
  
Synonyms : skib / v-ski avian sarcoma viral oncogene homolog b
  
Possible biological names infered from orthology : P12755 / SKI / SKI proto-oncogene
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 25782721
Gene end: 25829712
  
Corresponding Affymetrix probe sets: Dr.8083.1.S1_at (Zebrafish Array)   NM_130938_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000140149
Ensembl peptide - ENSDARP00000094325
NCBI entrez gene - 30113     See in Manteia.
RefSeq - NM_130938
RefSeq Peptide - NP_571013
swissprot - A0A0R4IX70
swissprot - Q9YI02
ZFIN ID - ZDB-GENE-990715-10
Ensembl - ENSDARG00000008034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SKIENSGALG00000001229Gallus gallus
 SKIENSG00000157933Homo sapiens
 SkiENSMUSG00000029050Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
skia / v-ski avian sarcoma viral oncogene homolog a / SKI* / P12755* / SKI proto-oncogene*ENSDARG0000004215164
skila / SKI-like proto-oncogene a / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSDARG0000002393332
skilb / SKI-like proto-oncogene b / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSDARG0000002290429
skor1a / SKI family transcriptional corepressor 1a / SKOR1* / P84550* / Q8BX46* / SKI family transcriptional corepressor 1*ENSDARG0000006903019
Q1LXZ9 / skor1b / SKI family transcriptional corepressor 1b / SKOR1* / Q8BX46* / P84550* / SKI family transcriptional corepressor 1*ENSDARG0000006244817
zgc:153395 / SKOR2* / Q2VWA4* / SKI family transcriptional corepressor 2*ENSDARG0000006361411


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028760  Ski oncogene


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0045596 negative regulation of cell differentiation IBA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0046332 SMAD binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord malformed , abnormal
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 ZFA:0000270 maxilla maxilla hyperplastic , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage flat , abnormal
Meckels cartilage shortened , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage increased variability of size , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage shortened , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction / complex
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / reaction / complex
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / reaction / complex
 ENSDARG00000000966 ncor2 / nuclear receptor corepressor 2 / Q9WU42* / Q9Y618*  / complex / reaction






 

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