ENSDARG00000027199


Danio rerio

Features
Gene ID: ENSDARG00000027199
  
Biological name :smad1
  
Synonyms : smad1 / SMAD family member 1
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 5 / P70340 / P97454 / Q15797 / Q99717 / SMAD5 / SMAD family member 5
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 35896488
Gene end: 35929143
  
Corresponding Affymetrix probe sets: Dr.8129.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000154860
Ensembl peptide - ENSDARP00000030150
Ensembl peptide - ENSDARP00000147187
Ensembl peptide - ENSDARP00000154401
NCBI entrez gene - 30628     See in Manteia.
RefSeq - XM_005159965
swissprot - Q5PQZ2
ZFIN ID - ZDB-GENE-991119-8
Ensembl - ENSDARG00000027199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMAD1ENSGALG00000009977Gallus gallus
 SMAD5ENSGALG00000006309Gallus gallus
 SMAD1ENSG00000170365Homo sapiens
 SMAD5ENSG00000113658Homo sapiens
 Smad1ENSMUSG00000031681Mus musculus
 Smad5ENSMUSG00000021540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *ENSDARG0000003723882
alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *ENSDARG0000002193878
smad3b / SMAD family member 3b / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000001020759
smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *ENSDARG0000000638959
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609659
smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*ENSDARG0000007522639
si:dkey-222b8.1ENSDARG0000004509436
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042836
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176325
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264924
smad7 / SMAD family member 7 / O15105* / O35253*ENSDARG0000001685823
smad6a / SMAD family member 6aENSDARG0000005320923


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0009880 embryonic pattern specification ISS
 biological_processGO:0030509 BMP signaling pathway ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000012 central nervous system central nervous system degenerate , abnormal
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 ZFA:0000017 endoderm endoderm morphology , abnormal
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 ZFA:0000019 epiphysis epiphysis cellular quality , abnormal
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 ZFA:0000032 hypothalamus hypothalamus cellular quality , abnormal
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 ZFA:0000040 median fin fold median fin fold cellular quality , abnormal
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 ZFA:0000077 tail bud tail bud cellular quality , abnormal
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 ZFA:0000094 blood island blood island morphology , abnormal
blood island has extra parts of type erythroid lineage cell , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
extension morphology , abnormal
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 ZFA:0000114 heart heart shape , abnormal
heart cellular quality , abnormal
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 ZFA:0000135 notochord notochord increased width , abnormal
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 ZFA:0000138 otic placode otic placode decreased size , abnormal
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 ZFA:0000152 retina retina dorsal region cellular quality , abnormal
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 ZFA:0000155 somite somite cellular quality , abnormal
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 ZFA:0000330 cloacal chamber cloacal chamber cellular quality , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism increased length , abnormal
whole organism dead , abnormal
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 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
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 ZFA:0001120 neuroectoderm neuroectoderm degenerate , abnormal
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 ZFA:0001161 pectoral fin pectoral fin cellular quality , abnormal
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 ZFA:0001290 stomodeum stomodeum cellular quality , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch cellular quality , abnormal
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 ZFA:0009048 granulocyte granulocyte decreased amount , abnormal
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 ZFA:0009141 macrophage macrophage decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / complex / reaction
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000075747 zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000008034 skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / reaction / complex
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / complex / reaction






 

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