ENSMUSG00000031681


Mus musculus

Features
Gene ID: ENSMUSG00000031681
  
Biological name :Smad1
  
Synonyms : P70340 / Smad1 / SMAD family member 1
  
Possible biological names infered from orthology : Q15797
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C1
Gene start: 79338395
Gene end: 79399518
  
Corresponding Affymetrix probe sets: 10579860 (MoGene1.0st)   1416081_at (Mouse Genome 430 2.0 Array)   1448208_at (Mouse Genome 430 2.0 Array)   1459843_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071035
Ensembl peptide - ENSMUSP00000105511
NCBI entrez gene - 17125     See in Manteia.
MGI - MGI:109452
RefSeq - XM_006530746
RefSeq - NM_008539
RefSeq Peptide - NP_032565
swissprot - P70340
swissprot - Q8C3Y6
Ensembl - ENSMUSG00000031681
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad1ENSDARG00000027199Danio rerio
 smad5ENSDARG00000037238Danio rerio
 SMAD1ENSGALG00000009977Gallus gallus
 SMAD1ENSG00000170365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*ENSMUSG0000002154090
Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*ENSMUSG0000002779678
Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*ENSMUSG0000002456361
Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*ENSMUSG0000003240260
Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*ENSMUSG0000002451539
Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*ENSMUSG0000003686725
Smad7 / O35253 / SMAD family member 7 / O15105*ENSMUSG0000002588023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily
 IPR036578  SMAD MH1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0001710 mesodermal cell fate commitment IGI
 biological_processGO:0002051 osteoblast fate commitment IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006954 inflammatory response IEP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007183 SMAD protein complex assembly IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009880 embryonic pattern specification ISS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0042592 homeostatic process IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051216 cartilage development IGI
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:0060348 bone development IGI
 biological_processGO:0060395 SMAD protein signal transduction IGI
 biological_processGO:0061036 positive regulation of cartilage development IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071773 cellular response to BMP stimulus IGI
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IGI
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0070410 co-SMAD binding IEA
 molecular_functionGO:0070411 I-SMAD binding IEA
 molecular_functionGO:0070878 primary miRNA binding IDA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Bmpr2tm1Mmue/Bmpr2+,Smad1tm1Rjle/Smad1+
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cyp27b1tm1Star/Cyp27b1tm1Star
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Smad1tm2Sor/Smad1tm2Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm2Sor

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad1tm2Sor/Smad1tm2Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm2Sor

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cyp27b1tm1Star/Cyp27b1tm1Star
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Cyp27b1tm1Star/Cyp27b1tm1Star
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Teftm1Schb/Teftm1Schb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0001711 abnormal placenta 
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0001749 suppressed circulating follicle stimulating hormone level "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:45065, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: involves: BALB/c * C57BL/6J * FVB/NJ

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Cyp27b1tm1Star/Cyp27b1tm1Star
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: involves: BALB/c * C57BL/6J * FVB/NJ

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003579 ovarian carcinoma 
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cyp27b1tm1Star/Cyp27b1tm1Star
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Smad1tm2Sor/Smad1tm2Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm2Sor

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cyp27b1tm1Star/Cyp27b1tm1Star
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004558 delayed allantois development "late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Tg(Prdm14-Venus)1Sait/0
Genetic Background: involves: 129S2/SvPas

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Tg(Prdm14-Venus)1Sait/0
Genetic Background: involves: 129S2/SvPas

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0006419 disorganized testis cords "derangement of the pattern of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm2Sor/Smad1tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Smad1tm1Sor/Smad1tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Tako/Smad1tm1Tako
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

Allelic Composition: Smad1tm2Sor/Smad1tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm2Sor/Smad1tm2Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm2Sor

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Tako/Smad1tm1Tako
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0010642 absent third branchial arch "absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr2tm1Mmue/Bmpr2+,Smad1tm1Rjle/Smad1+
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

 MP:0010779 abnormal stomach muscularis externa morphology "any structural anomaly of the smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: 129S4/SvJaeSor-Smad1tm1Sor

Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Tako/Smad1tm1Tako
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Smad1tm1Rob/Smad1+,Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0012134 absent umbilical cord "absence of or failure to form the connective stalk between the fetus and the placenta" [MGI:anna]
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Allelic Composition: Smad1tm1Rob/Smad1tm1Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2.1Rob,Smad5tm1Huy/Smad5tm1Huy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0030439 decreased osteoblast proliferation "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / reaction / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / reaction / complex
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / reaction / complex
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / reaction / complex
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / reaction / complex
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / reaction / complex
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000029050 Ski / SKI proto-oncogene / P12755*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / reaction / complex
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / complex / reaction






 

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