ENSDARG00000037238


Danio rerio

Features
Gene ID: ENSDARG00000037238
  
Biological name :smad5
  
Synonyms : Q9W7E7 / smad5 / SMAD family member 5
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 5 / P70340 / P97454 / Q15797 / Q99717 / SMAD1 / SMAD family member 1
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 26467120
Gene end: 26498325
  
Corresponding Affymetrix probe sets: Dr.20558.1.S1_at (Zebrafish Array)   Dr.26149.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000153815
Ensembl peptide - ENSDARP00000155132
Ensembl peptide - ENSDARP00000154529
Ensembl peptide - ENSDARP00000054174
Ensembl peptide - ENSDARP00000121034
Ensembl peptide - ENSDARP00000149901
NCBI entrez gene - 30641     See in Manteia.
RefSeq - NM_001346309
RefSeq - XM_005173164
RefSeq - NM_131368
RefSeq Peptide - NP_571443
RefSeq Peptide - NP_001333238
swissprot - A5PMC0
swissprot - A5PMB9
swissprot - Q9W7E7
ZFIN ID - ZDB-GENE-990603-9
Ensembl - ENSDARG00000037238
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMAD1ENSGALG00000009977Gallus gallus
 SMAD5ENSGALG00000006309Gallus gallus
 SMAD1ENSG00000170365Homo sapiens
 SMAD5ENSG00000113658Homo sapiens
 Smad1ENSMUSG00000031681Mus musculus
 Smad5ENSMUSG00000021540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *ENSDARG0000002719983
alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *ENSDARG0000002193879
smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *ENSDARG0000000638962
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609661
smad3b / SMAD family member 3b / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000001020761
smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*ENSDARG0000007522639
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042837
si:dkey-222b8.1ENSDARG0000004509437
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176325
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264925
smad6a / SMAD family member 6aENSDARG0000005320924
smad7 / SMAD family member 7 / O15105* / O35253*ENSDARG0000001685823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0030509 BMP signaling pathway IGI
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0043049 otic placode formation IEP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048514 blood vessel morphogenesis IGI
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0048922 posterior lateral line neuromast deposition IMP
 biological_processGO:0060022 hard palate development IMP
 biological_processGO:0060030 dorsal convergence IMP
 biological_processGO:0060037 pharyngeal system development IMP
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000019 epiphysis epiphysis has fewer parts of type photoreceptor cell , abnormal
Show

 ZFA:0000022 floor plate floor plate increased width , abnormal
Show

 ZFA:0000029 hindbrain hindbrain condensed , abnormal
Show

 ZFA:0000040 median fin fold median fin fold hypoplastic , abnormal
Show

 ZFA:0000077 tail bud tail bud protruding , abnormal
tail bud increased size , abnormal
tail bud mislocalised , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
Show

 ZFA:0000138 otic placode otic placode decreased size , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct decreased length , abnormal
Show

 ZFA:0000151 pronephros pronephros increased width , abnormal
Show

 ZFA:0000152 retina retina dorsal region cellular quality , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite morphology , abnormal
somite decreased amount , abnormal
somite circular , abnormal
somite increased width , abnormal
somite cellular quality , abnormal
Show

 ZFA:0000180 caudal vein caudal vein truncated , abnormal
caudal vein absent , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm morphology , abnormal
paraxial mesoderm has extra parts of type adaxial cell , abnormal
paraxial mesoderm anterior-posterior axis decreased length , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000330 cloacal chamber cloacal chamber cellular quality , abnormal
Show

 ZFA:0000547 mouth mouth quality , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 increased length , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
posterior lateral line neuromast far from posterior lateral line neuromast , abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 increased length , abnormal
Show

 ZFA:0001058 caudal fin caudal fin hypoplastic , abnormal
caudal fin ventral region hypoplastic , abnormal
caudal fin aplastic , abnormal
caudal fin decreased length , abnormal
caudal fin kinked , abnormal
caudal fin increased accumulation blood cell , abnormal
caudal fin wholly dorsalized , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold hypoplastic , abnormal
ventral fin fold morphology , abnormal
ventral fin fold flattened , abnormal
ventral fin fold edge shape , abnormal
ventral fin fold postero-ventral region hypoplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism wholly dorsalized , abnormal
whole organism viability , abnormal
whole organism shape , abnormal
whole organism elongated , abnormal
whole organism has extra parts of type post-vent region , abnormal
Show

 ZFA:0001115 trunk trunk condensed , abnormal
Show

 ZFA:0001117 post-vent region post-vent region structure , abnormal
post-vent region quality , abnormal
post-vent region truncated , abnormal
post-vent region curved , abnormal
post-vent region decreased length , abnormal
post-vent region has extra parts of type tail bud , abnormal
post-vent region has extra parts of type notochord , abnormal
post-vent region aplastic , abnormal
post-vent region kinked , abnormal
post-vent region shortened , abnormal
post-vent region increased curvature , abnormal
Show

 ZFA:0001130 pharyngeal pouch 2 pharyngeal pouch 2 malformed , abnormal
Show

 ZFA:0001162 anal fin anal fin hypoplastic , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage position , abnormal
Meckels cartilage decreased length , abnormal
Meckels cartilage overlap with Meckels cartilage , abnormal
Meckels cartilage morphology , abnormal
Meckels cartilage decreased size , abnormal
Meckels cartilage fused with cartilage element , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium malformed , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus aplastic , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch malformed , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage fused with ceratobranchial 1 cartilage , abnormal
ceratohyal cartilage morphology , abnormal
ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage fused with cartilage element , abnormal
ceratohyal cartilage fused with ceratobranchial cartilage , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage absent , abnormal
ethmoid cartilage aplastic , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage morphology , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage condensed , abnormal
pharyngeal arch cartilage morphology , abnormal
Show

 ZFA:0001507 trabecula cranii trabecula cranii decreased length , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased amount , abnormal
Show

 ZFA:0001609 pharyngeal arch 6 pharyngeal arch 6 absent , abnormal
Show

 ZFA:0001610 pharyngeal arch 7 pharyngeal arch 7 absent , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 fused with pharyngeal arch 3 , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct has fewer parts of type lymphatic system endothelial cell, abnormal
Show

 ZFA:0005768 trigeminal sensory neuron trigeminal sensory neuron decreased amount , abnormal
Show

 ZFA:0009004 trunk neural crest cell trunk neural crest cell decreased amount , abnormal
Show

 ZFA:0009051 interneuron interneuron increased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0009265 monocyte monocyte increased amount , abnormal
Show

 ZFA:0009325 erythroid lineage cell erythroid lineage cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / complex / reaction
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / reaction / complex
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000008034 skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000075747 zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / complex / reaction
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr